Intraspinal stimulation with light activated micro-stimulators

Ammar Abdo; Mesut Sahin; David S. Freedman; Elif Cevik; Philipp S. Spuhler; M. Selim Unlu

doi:10.1109/NER.2011.5910606

Intraspinal stimulation with light activated micro-stimulators

Ammar Abdo, Mesut Sahin, David S. Freedman, Elif Cevik, Philipp S. Spuhler, M. Selim Unlu

Bio-Medical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

Chronic tissue response to microelectrode implants stands in the way as a major challenge to development of many neural prosthetic applications. The long term tissue response is mostly due to the movement of interconnects and the resulting mechanical stress between the electrode and the surrounding neural tissue. Wireless microstimulators are a potential solution to the problem. As a method of energy transfer to the microstimulator, we propose to use a laser beam at near infrared (NIR) wavelengths. Microstimulators of various sizes were fabricated with two cascaded GaAs PIN photodiodes. The voltage field of the device was measured in saline solution as a response to an NIR laser source. The voltage in medium had a peak of around 190 mV above the cathodic contact and stayed flat for the duration of 0.2 ms pulse. In rats, microstimulators were inserted into the ventral horn of cervical spinal cord. A train of NIR pulses (0.2 ms, 100 Hz) were applied to wirelessly activate the devices. The forces generated due to stimulation of the motor neurons were measured from the ipsilateral forelimb with a force transducer. The largest force generated was around 0.9 N. The volume conductor and force measurements suggest that the floating light activated micro-electrical stimulator (FLAMES) approach is feasible for intraspinal stimulation.

Original language	English (US)
Title of host publication	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
Pages	546-549
Number of pages	4
DOIs	https://doi.org/10.1109/NER.2011.5910606
State	Published - 2011
Event	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 - Cancun, Mexico Duration: Apr 27 2011 → May 1 2011

Publication series

Name	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011

Other

Other	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
Country/Territory	Mexico
City	Cancun
Period	4/27/11 → 5/1/11

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

neural microstimulation
wireless microstimulators

Access to Document

10.1109/NER.2011.5910606

Cite this

Abdo, A., Sahin, M., Freedman, D. S., Cevik, E., Spuhler, P. S., & Unlu, M. S. (2011). Intraspinal stimulation with light activated micro-stimulators. In 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 (pp. 546-549). Article 5910606 (2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011). https://doi.org/10.1109/NER.2011.5910606

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title = "Intraspinal stimulation with light activated micro-stimulators",

abstract = "Chronic tissue response to microelectrode implants stands in the way as a major challenge to development of many neural prosthetic applications. The long term tissue response is mostly due to the movement of interconnects and the resulting mechanical stress between the electrode and the surrounding neural tissue. Wireless microstimulators are a potential solution to the problem. As a method of energy transfer to the microstimulator, we propose to use a laser beam at near infrared (NIR) wavelengths. Microstimulators of various sizes were fabricated with two cascaded GaAs PIN photodiodes. The voltage field of the device was measured in saline solution as a response to an NIR laser source. The voltage in medium had a peak of around 190 mV above the cathodic contact and stayed flat for the duration of 0.2 ms pulse. In rats, microstimulators were inserted into the ventral horn of cervical spinal cord. A train of NIR pulses (0.2 ms, 100 Hz) were applied to wirelessly activate the devices. The forces generated due to stimulation of the motor neurons were measured from the ipsilateral forelimb with a force transducer. The largest force generated was around 0.9 N. The volume conductor and force measurements suggest that the floating light activated micro-electrical stimulator (FLAMES) approach is feasible for intraspinal stimulation.",

keywords = "neural microstimulation, wireless microstimulators",

author = "Ammar Abdo and Mesut Sahin and Freedman, {David S.} and Elif Cevik and Spuhler, {Philipp S.} and Unlu, {M. Selim}",

year = "2011",

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language = "English (US)",

isbn = "9781424441402",

series = "2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011",

pages = "546--549",

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note = "2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 ; Conference date: 27-04-2011 Through 01-05-2011",

}

Abdo, A, Sahin, M, Freedman, DS, Cevik, E, Spuhler, PS & Unlu, MS 2011, Intraspinal stimulation with light activated micro-stimulators. in 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011., 5910606, 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011, pp. 546-549, 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011, Cancun, Mexico, 4/27/11. https://doi.org/10.1109/NER.2011.5910606

Intraspinal stimulation with light activated micro-stimulators. / Abdo, Ammar; Sahin, Mesut; Freedman, David S. et al.
2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011. 2011. p. 546-549 5910606 (2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - Chronic tissue response to microelectrode implants stands in the way as a major challenge to development of many neural prosthetic applications. The long term tissue response is mostly due to the movement of interconnects and the resulting mechanical stress between the electrode and the surrounding neural tissue. Wireless microstimulators are a potential solution to the problem. As a method of energy transfer to the microstimulator, we propose to use a laser beam at near infrared (NIR) wavelengths. Microstimulators of various sizes were fabricated with two cascaded GaAs PIN photodiodes. The voltage field of the device was measured in saline solution as a response to an NIR laser source. The voltage in medium had a peak of around 190 mV above the cathodic contact and stayed flat for the duration of 0.2 ms pulse. In rats, microstimulators were inserted into the ventral horn of cervical spinal cord. A train of NIR pulses (0.2 ms, 100 Hz) were applied to wirelessly activate the devices. The forces generated due to stimulation of the motor neurons were measured from the ipsilateral forelimb with a force transducer. The largest force generated was around 0.9 N. The volume conductor and force measurements suggest that the floating light activated micro-electrical stimulator (FLAMES) approach is feasible for intraspinal stimulation.

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Intraspinal stimulation with light activated micro-stimulators

Abstract

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Keywords

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