Iodine-mediated oxidation of ynamides: A facile access to N-monosubstituted α-ketoamides and α-ketoimides

Hai Huang; Guangke He; Xiaolin Zhu; Xiaodong Jin; Shineng Qiu; Hongjun Zhu

doi:10.1002/ejoc.201402538

Iodine-mediated oxidation of ynamides: A facile access to N-monosubstituted α-ketoamides and α-ketoimides

Hai Huang, Guangke He, Xiaolin Zhu, Xiaodong Jin, Shineng Qiu, Hongjun Zhu

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst.

Original language	English (US)
Pages (from-to)	7174-7183
Number of pages	10
Journal	European Journal of Organic Chemistry
Volume	2014
Issue number	32
DOIs	https://doi.org/10.1002/ejoc.201402538
State	Published - Nov 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry
Organic Chemistry

Keywords

Alkynes
Amides
Iodine
Oxidation
Synthetic methods

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10.1002/ejoc.201402538

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title = "Iodine-mediated oxidation of ynamides: A facile access to N-monosubstituted α-ketoamides and α-ketoimides",

abstract = "An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst.",

keywords = "Alkynes, Amides, Iodine, Oxidation, Synthetic methods",

author = "Hai Huang and Guangke He and Xiaolin Zhu and Xiaodong Jin and Shineng Qiu and Hongjun Zhu",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2014",

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doi = "10.1002/ejoc.201402538",

language = "English (US)",

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T1 - Iodine-mediated oxidation of ynamides

T2 - A facile access to N-monosubstituted α-ketoamides and α-ketoimides

AU - Huang, Hai

AU - He, Guangke

AU - Zhu, Xiaolin

AU - Jin, Xiaodong

AU - Qiu, Shineng

AU - Zhu, Hongjun

PY - 2014/11

Y1 - 2014/11

N2 - An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst.

AB - An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst.

KW - Alkynes

KW - Amides

KW - Iodine

KW - Oxidation

KW - Synthetic methods

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U2 - 10.1002/ejoc.201402538

DO - 10.1002/ejoc.201402538

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VL - 2014

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EP - 7183

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 32

ER -

Iodine-mediated oxidation of ynamides: A facile access to N-monosubstituted α-ketoamides and α-ketoimides

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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