Iodine-mediated oxidation of ynamides: A facile access to N-monosubstituted α-ketoamides and α-ketoimides

Hai Huang, Guangke He, Xiaolin Zhu, Xiaodong Jin, Shineng Qiu, Hongjun Zhu

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst.

Original languageEnglish (US)
Pages (from-to)7174-7183
Number of pages10
JournalEuropean Journal of Organic Chemistry
Volume2014
Issue number32
DOIs
StatePublished - Nov 2014

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Keywords

  • Alkynes
  • Amides
  • Iodine
  • Oxidation
  • Synthetic methods

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