Ionic current correlations underlie the global tuning of large numbers of neuronal activity attributes

Shunbing Zhao, Jorge Golowasch

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Ionic conductances in identified neurons are highly variable. This poses the crucial question of how such neurons can produce stable activity. Coexpression of ionic currents has been observed in an increasing number of neurons in different systems, suggesting that the coregulation of ionic channel expression, by thus linking their variability, may enable neurons to maintain relatively constant neuronal activity as suggested by a number of recent theoretical studies. We examine this hypothesis experimentally using the voltage- and dynamic-clamp techniques to first measure and then modify the ionic conductance levels of three currents in identified neurons of the crab pyloric network. We quantify activity by measuring 10 different attributes (oscillation period, spiking frequency, etc.), and find linear, positive and negative relationships between conductance pairs and triplets that can enable pyloric neurons to maintain activity attributes invariant. Consistent with experimental observations, some of the features most tightly regulated appear to be phase relationships of bursting activity. We conclude that covariation (and probably a tightly controlled coregulation) of ionic conductances can help neurons maintain certain attributes of neuronal activity invariant while at the same time allowing conductances to change over wide ranges in response to internal or environmental inputs and perturbations. Our results also show that neurons can tune neuronal activity globally via coordinate expression of ion currents.

Original languageEnglish (US)
Pages (from-to)13380-13388
Number of pages9
JournalJournal of Neuroscience
Volume32
Issue number39
DOIs
StatePublished - Sep 26 2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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