Ir vibrational CD in model deoxyoligonucleotides: Observation of the B → Z phase transition and extended coupled oscillator intensity calcuations

Miriam Gulotta, Dixie J. Goss, Max Diem

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

The first observation of ir vibrational CD (VCD) in small model DNA molecules is reported. The VCD signals in the 1550–1750‐cm−1 spectral region, which originate from coupling of carbonyl stretching modes of the nucleic acid bases, are found to be sensitive to the handedness of the polymer helix. The formalism to calculate VCD intensities of polymers is developed from the exciton model derived earlier by Tinoco [(1963) Radiation Res. 20, 133; (1960) J. Chem. Phys. 33, 1332; (1964) J. Am. Chem. Soc. 86, 297] and Schellman and co‐workers [(1975) Biopolymers 14, 173; (1969) J. Phys. Chem. 73, 28]. The resulting equations, which are a direct extension of the dimeric case known as the “coupled oscillator,” are used in model calculations of the helical polymers.

Original languageEnglish (US)
Pages (from-to)2047-2058
Number of pages12
JournalBiopolymers
Volume28
Issue number12
DOIs
StatePublished - Dec 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

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