Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes

Manish Chhowalla, H. Emrah Unalan, Yubing Wang, Zafar Iqbal, Kiho Park, Federico Sesti

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

We demonstrate irreversible blocking of ion channels using single-wall carbon nanotubes (SWNTs) functionalized with 2-aminoethylmethane thiosulfonate (MTSET). In contrast, as-produced and purified SWNTs exhibit reversible blocking, indicating that the MTSET molecule attached to SWNTs chemically interacts with the cysteine groups in the ion channels. Functionalization of SWNTs with MTSET is inferred from Fourier transform infrared (FTIR) spectroscopy, which clearly shows absorptions due to -CH stretching and deformation modes, and decrease in intensity of the -COOH line due to reaction of acid functionalized SWNTs with the basic N-CH3 end of the MTSET molecule.

Original languageEnglish (US)
Pages (from-to)2982-2986
Number of pages5
JournalNanotechnology
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2005

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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