Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes

Manish Chhowalla; H. Emrah Unalan; Yubing Wang; Zafar Iqbal; Kiho Park; Federico Sesti

doi:10.1088/0957-4484/16/12/042

Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes

Manish Chhowalla, H. Emrah Unalan, Yubing Wang, Zafar Iqbal, Kiho Park, Federico Sesti

Chemistry and Environmental Science

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

We demonstrate irreversible blocking of ion channels using single-wall carbon nanotubes (SWNTs) functionalized with 2-aminoethylmethane thiosulfonate (MTSET). In contrast, as-produced and purified SWNTs exhibit reversible blocking, indicating that the MTSET molecule attached to SWNTs chemically interacts with the cysteine groups in the ion channels. Functionalization of SWNTs with MTSET is inferred from Fourier transform infrared (FTIR) spectroscopy, which clearly shows absorptions due to -CH stretching and deformation modes, and decrease in intensity of the -COOH line due to reaction of acid functionalized SWNTs with the basic N-CH₃ end of the MTSET molecule.

Original language	English (US)
Pages (from-to)	2982-2986
Number of pages	5
Journal	Nanotechnology
Volume	16
Issue number	12
DOIs	https://doi.org/10.1088/0957-4484/16/12/042
State	Published - Dec 1 2005

All Science Journal Classification (ASJC) codes

Bioengineering
General Chemistry
General Materials Science
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

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10.1088/0957-4484/16/12/042

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title = "Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes",

abstract = "We demonstrate irreversible blocking of ion channels using single-wall carbon nanotubes (SWNTs) functionalized with 2-aminoethylmethane thiosulfonate (MTSET). In contrast, as-produced and purified SWNTs exhibit reversible blocking, indicating that the MTSET molecule attached to SWNTs chemically interacts with the cysteine groups in the ion channels. Functionalization of SWNTs with MTSET is inferred from Fourier transform infrared (FTIR) spectroscopy, which clearly shows absorptions due to -CH stretching and deformation modes, and decrease in intensity of the -COOH line due to reaction of acid functionalized SWNTs with the basic N-CH3 end of the MTSET molecule.",

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T1 - Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes

AU - Chhowalla, Manish

AU - Unalan, H. Emrah

AU - Wang, Yubing

AU - Iqbal, Zafar

AU - Park, Kiho

AU - Sesti, Federico

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We demonstrate irreversible blocking of ion channels using single-wall carbon nanotubes (SWNTs) functionalized with 2-aminoethylmethane thiosulfonate (MTSET). In contrast, as-produced and purified SWNTs exhibit reversible blocking, indicating that the MTSET molecule attached to SWNTs chemically interacts with the cysteine groups in the ion channels. Functionalization of SWNTs with MTSET is inferred from Fourier transform infrared (FTIR) spectroscopy, which clearly shows absorptions due to -CH stretching and deformation modes, and decrease in intensity of the -COOH line due to reaction of acid functionalized SWNTs with the basic N-CH3 end of the MTSET molecule.

AB - We demonstrate irreversible blocking of ion channels using single-wall carbon nanotubes (SWNTs) functionalized with 2-aminoethylmethane thiosulfonate (MTSET). In contrast, as-produced and purified SWNTs exhibit reversible blocking, indicating that the MTSET molecule attached to SWNTs chemically interacts with the cysteine groups in the ion channels. Functionalization of SWNTs with MTSET is inferred from Fourier transform infrared (FTIR) spectroscopy, which clearly shows absorptions due to -CH stretching and deformation modes, and decrease in intensity of the -COOH line due to reaction of acid functionalized SWNTs with the basic N-CH3 end of the MTSET molecule.

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Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes

Abstract

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