Laminar Dispersive and Distributive Mixing with Dissolution and Applications to Hot-Melt Extrusion

Costas G. Gogos, Huiju Liu, Peng Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations
Original languageEnglish (US)
Title of host publicationHot-Melt Extrusion
Subtitle of host publicationPharmaceutical Applications
PublisherJohn Wiley and Sons
Pages261-284
Number of pages24
ISBN (Print)9780470711187
DOIs
StatePublished - Apr 26 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Keywords

  • APAP and PEO, one category of drug-polymer mixtures
  • Back (axial) mixing, on compositional uniformity of HME products
  • Co-TSEs and PED, its significance
  • Dispersive and distributive mixing
  • Drag-induced pumping, pressurization, enabling co-TSEs and SSEs
  • Drug particulate dissolution in polymeric melt
  • Laminar dispersive, distributive mixing and HME
  • Polymer-compounding, conceptual structural breakdown

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