Lanthanide-doped upconversion nanoparticles for imaging-guided drug delivery and therapy

Z. Li, Y. Zhang, G. Han

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Lanthanide-doped upconversion nanoparticles (UCNPs) possess unique anti-Stokes optical properties, in which low-energy near-infrared (NIR) excitation can be converted into high-energy UV and/or visible emission with pronounced luminescence and chemical stability. Due to the rapid development of synthesis chemistry, lanthanide-doped UCNPs can be fabricated with narrow distribution and modulated physical behaviors. These unique characters endow them unique NIR-driven imaging/delivery/therapeutic applications, especially in the cases of the deep tissue environments. Herein, we introduce both the basic concepts and the up-to-date progresses of UCNPs in material engineering, toxicology, and bio-applications in imaging, molecular delivery, and tumor therapeutics.

Original languageEnglish (US)
Pages (from-to)139-164
Number of pages26
JournalSpringer Series in Biomaterials Science and Engineering
Volume6
DOIs
StatePublished - 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biomaterials

Keywords

  • Drug delivery
  • Optical imaging
  • Optical therapy
  • Upconversion nanoparticles

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