Long-Lasting Suppression of Acoustic Startle Response after Mild Traumatic Brain Injury

Kevin C.H. Pang, Swamini Sinha, Pelin Avcu, Jessica J. Roland, Neil Nadpara, Bryan Pfister, Mathew Long, Vijayalakshmi Santhakumar, Richard J. Servatius

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Abstract Acoustic startle response (ASR) is a defensive reflex that is largely ignored unless greatly exaggerated. ASR is suppressed after moderate and severe traumatic brain injury (TBI), but the effect of mild TBI (mTBI) on ASR has not been investigated. Because the neural circuitry for ASR resides in the pons in all mammals, ASR may be a good measure of brainstem function after mTBI. The present study assessed ASR in Sprague-Dawley rats after mTBI using lateral fluid percussion and compared these effects to those on spatial working memory. mTBI caused a profound, long-lasting suppression of ASR. Both probability of emitting a startle and startle amplitude were diminished. ASR suppression was observed as soon as 1 day after injury and remained suppressed for the duration of the study (21 days after injury). No indication of recovery was observed. mTBI also impaired spatial working memory. In contrast to the suppression of ASR, working memory impairment was transient; memory was impaired 1 and 7 days after injury, but recovered by 21 days. The long-lasting suppression of ASR suggests long-term dysfunction of brainstem neural circuits at a time when forebrain neural circuits responsible for spatial working memory have recovered. These results have important implications for return-to-activity decisions because recovery of cognitive impairments plays an important role in these decisions.

Original languageEnglish (US)
Pages (from-to)801-810
Number of pages10
JournalJournal of Neurotrauma
Volume32
Issue number11
DOIs
StatePublished - Jun 1 2015

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Keywords

  • Concussion
  • Lateral fluid percussion
  • Memory
  • Pons
  • Spatial learning

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