Abstract
A facile method is developed for the fabrication of magnetic iron oxide nanoparticle-hollow mesoporous silica spheres (IONP-HMSs) and explored their potential application in drug delivery. Through the self-assembling process of IONPs and the formation of mesoporous silica shells, the IONP-HMSs with hollow interior cavity were obtained. The cetyltrimethyl ammonium bromide (CTAB) encapsulated IONP-containing spheres served as the template to establish the mesoporous silica shells. Typical anti-cancer drug, doxorubicin hydrochloride (DOX) was applied for drug loading and release process of IONP-HMSs, which demonstrated the IONP-HMSs have a high drug loading efficiency and allow pH-trigged release of DOX in vitro. Moreover, the IONP-HMSs exhibited excellent biocompatibility and enhanced DOX therapeutic efficacy to HeLa cells. Compared with traditional methods, the reported microemulsion-based method for the synthesis of IONP-HMSs enables the formation of hollow-structured nanocomposite without any complex template-removing process, which could pave the way to improving the therapeutic efficacy in drug delivery system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 320-325 |
| Number of pages | 6 |
| Journal | Current Applied Physics |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2020 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Materials Science
- General Physics and Astronomy
Keywords
- Adsorption capacity and loading efficiency
- Cell viability
- Magnetic nanoparticles
- Mesoporous silica spheres
- pH-triggred release