Magnetic porous carbon derived from a zinc-cobalt metal-organic framework: A adsorbent for magnetic solid phase extraction of flunitrazepam

Qiuhua Wu, Si Cheng, Chenhuan Wang, Xiyang Li, Zhi Li, Chen Hao

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Nanoporous carbon that contains magnetic cobalt nanoparticles (Co-NPC) was fabricated by direct carbonization of a Zn-Co bimetallic zeolitic imidazolate framework. After carbonization, the magnetic Co-NPs are well dispersed in the porous carbon matrix, with the result that the Co-NPC displays strong magnetism. The Co-NPC possesses a high specific surface area, large pore volumes and a microstructure comprised of mesopores and macropores. This results in fast molecular diffusion of the analytes along with excellent adsorption. The Co-NPC was used as a magnetic adsorbent for the enrichment of the benzodiazepine drug flunitrazepam (rohypnol) from tea and Ginger ale prior to high-resolution mass spectrometric analysis. The calibration plot is linear (with a correlation coefficient of >0.9869) in the 1 to 500 ng mL−1 concentration range. The limits of detection are 0.2 ng mL−1 for Ginger ale and 1.0 ngmL−1 for Arizona Tea samples, respectively, which is lower by about 4 orders of magnitude than those reported in the literature. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)3009-3017
Number of pages9
JournalMicrochimica Acta
Volume183
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Keywords

  • Adsorption-desorption isotherms
  • Bimetallic metal-organic framework
  • Ginger ale analysis
  • Magnetic solid phase extraction
  • Mass spectrometry
  • Porous material
  • Scanning electron microscopy
  • Tea analysis
  • Transmission electron microscopy
  • Vibrating sample magnetometry

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