Abstract
Magnetic biodetection systems based on the magnetic properties of nanoparticles have received considerable attention because most biological samples exhibit no magnetic background and highly sensitive measurements can be performed in visually obscured biological samples. Magnetic iron oxide nanoparticles (IONPs) emerge as an excellent candidate because they are physically and chemically stable, bio-compatible, environmentally safe, and inexpensive to produce. This review focuses on the IONP-based magnetic biodetection and how the magnetic properties of IONPs are used to determine the presence of the bound bioanalytes. The magnetic permeability, magnetic relaxation, and stray magnetic field of IONPs are elaborated and the mechanism they are being applied in magnetic biodetection is explained. Information about the typical chemical synthesis methods and the properties of the IONP products are summarized. Recent advances on the magnetic biodetection with IONPs are explored. Moreover, the prospect of using IONP-based magnetic biodetection to provide a multiplexing and miniaturized testing platform for health care is revealed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 397-414 |
| Number of pages | 18 |
| Journal | Journal of Nanoelectronics and Optoelectronics |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2013 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Electrical and Electronic Engineering
Keywords
- Iron oxide nanoparticles
- Magnetic biodetection
- Magnetic relaxation
- Magnetic susceptibility
- Stray magnetic field