@article{7c22096baf6d45c9acc6e8b4e8b06636,
title = "Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae",
abstract = "Mammals cannot see light over 700 nm in wavelength. This limitation is due to the physical thermodynamic properties of the photon-detecting opsins. However, the detection of naturally invisible near-infrared (NIR) light is a desirable ability. To break this limitation, we developed ocular injectable photoreceptor-binding upconversion nanoparticles (pbUCNPs). These nanoparticles anchored on retinal photoreceptors as miniature NIR light transducers to create NIR light image vision with negligible side effects. Based on single-photoreceptor recordings, electroretinograms, cortical recordings, and visual behavioral tests, we demonstrated that mice with these nanoantennae could not only perceive NIR light, but also see NIR light patterns. Excitingly, the injected mice were also able to differentiate sophisticated NIR shape patterns. Moreover, the NIR light pattern vision was ambient-daylight compatible and existed in parallel with native daylight vision. This new method will provide unmatched opportunities for a wide variety of emerging bio-integrated nanodevice designs and applications. Video Abstract: Injectable photoreceptor-binding nanoparticles with the ability to convert photons from low-energy to high-energy forms allow mice to develop infrared vision without compromising their normal vision and associated behavioral responses.",
keywords = "biocompatibility, image vision, nanoantenna, near-infrared light, photoreceptors, retina, spectrum, upconversion nanoparticle, visual behavior, visual enhancement",
author = "Yuqian Ma and Jin Bao and Yuanwei Zhang and Zhanjun Li and Xiangyu Zhou and Changlin Wan and Ling Huang and Yang Zhao and Gang Han and Tian Xue",
note = "Funding Information: We thank members of the Neuroscience Pioneer Club for valuable discussions. We thank Drs. Dangsheng Li and Zilong Qiu for reading this manuscript and providing helpful comments. We thank Dr. Yang Xiang from University of Massachusetts Medical School for helpful discussion. We thank Min Wei and Shouzhen Li for helpful discussions and Jiawei Shen and Dr. Huan Zhao for helping illustration drawing and videos clipping. We thank Dr. Kai Huang and Mr. Nuo Yu for helping characterizing nanoparticles. We thank Dr. Qiuping Wang and Xiaokang Ding from National Synchrotron Radiation Laboratory for helping with the measurement of various spectra of light sources. We thank Dr. Yuen Wu and Xing Wang from School of Chemistry and Materials Science (USTC) for helping with the measurement of the absorption spectrum of pbUCNPs. We acknowledge support from the National Key Research and Development Program of China ( 2016YFA0400900 ), the Strategic Priority Research Program of the Chinese Academy of Science ( XDA16020603 , XDPB10 , XDB02010000 ), the National Young Scientists 973 Program of China ( 2013CB967700 ), the National Natural Science Foundation of China ( 81790644 , 61890953 , 31322024 , 81371066 , 91432104 , 31571073 , 81401025 , 61727811 , 91748212 ), the NIH ( R01MH103133 to G.H.), a UMass OTCV award, a Worcester Foundation Mel Cutler Award to G.H., and the Human Frontier Science Program ( RGY-0090/2014 ). Funding Information: We thank members of the Neuroscience Pioneer Club for valuable discussions. We thank Drs. Dangsheng Li and Zilong Qiu for reading this manuscript and providing helpful comments. We thank Dr. Yang Xiang from University of Massachusetts Medical School for helpful discussion. We thank Min Wei and Shouzhen Li for helpful discussions and Jiawei Shen and Dr. Huan Zhao for helping illustration drawing and videos clipping. We thank Dr. Kai Huang and Mr. Nuo Yu for helping characterizing nanoparticles. We thank Dr. Qiuping Wang and Xiaokang Ding from National Synchrotron Radiation Laboratory for helping with the measurement of various spectra of light sources. We thank Dr. Yuen Wu and Xing Wang from School of Chemistry and Materials Science (USTC) for helping with the measurement of the absorption spectrum of pbUCNPs. We acknowledge support from the National Key Research and Development Program of China (2016YFA0400900), the Strategic Priority Research Program of the Chinese Academy of Science (XDA16020603, XDPB10, XDB02010000), the National Young Scientists 973 Program of China (2013CB967700), the National Natural Science Foundation of China (81790644, 61890953, 31322024, 81371066, 91432104, 31571073, 81401025, 61727811, 91748212), the NIH (R01MH103133 to G.H.), a UMass OTCV award, a Worcester Foundation Mel Cutler Award to G.H. and the Human Frontier Science Program (RGY-0090/2014). Conceptualization, T.X. and G.H.; Methodology, Y.M. J.B. G.H. and T.X.; Investigation, Y.M. J.B. Y. Zhang, Z.L. L.H. Y. Zhao, X.Z. C.W. G.H. and T.X.; Validation, J.B. G.H. and T.X.; Formal Analysis, Y.M. and J.B.; Writing – Original Draft, J.B. Y.M. Y. Zhang, G.H. and T.X.; Writing – Review & Editing, J.B. Y.M. G.H. and T.X.; Funding Acquisition, J.B. G.H. and T.X.; Supervision, J.B. G.H. and T.X. T.X. and G.H. have a patent application related to this work. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = apr,
day = "4",
doi = "10.1016/j.cell.2019.01.038",
language = "English (US)",
volume = "177",
pages = "243--255.e15",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}