Membrane distillation as an online concentration technique: Application to the determination of pharmaceutical residues in natural waters

Ken Gethard, Somenath Mitra

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Membrane distillation (MD) is presented for the first time as a real-time, online concentration technique, where the aqueous matrix is removed from the sample to enhance analyte enrichment. Therefore, MD is a universal method for a wide range of compounds and is unlike conventional membrane extractions that rely on the permeation of the solute into an extractant phase. The MD process showed excellent precision with relative standard deviation between 3% and 5%, linear calibration, and the detection limits for pharmaceutical compounds in the range of 0.01 to 20 mg L-1 by HPLC-UV analysis. The temperature and flow rate of the feed solution were found to be important variables.

Original languageEnglish (US)
Pages (from-to)571-575
Number of pages5
JournalAnalytical and Bioanalytical Chemistry
Volume400
Issue number2
DOIs
StatePublished - Apr 2011

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry

Keywords

  • Enrichment factor
  • Hollow fiber membrane
  • Membrane distillation
  • Solvent reduction

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