Membrane systems for pharmaceutical applications

Dimitrios Zarkadas, Kamalesh K. Sirkar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There have been limited applications of membrane technologies in the pharmaceutical industry during active pharmaceutical ingredient (API) processing in the presence of organic solvents. The membrane technologies that are being used and/or explored in a more than cursory fashion in pharmaceutical processing are pervaporation and organic solvent nanofiltration. The majority of potential pervaporation applications in the pharmaceutical industry are related to dehydration of pharmaceutical streams. This chapter examines in more detail the work that has been performed up to now in the dehydration of organic solvents with ceramic membranes for two reasons. First, ceramic membranes are considered the most appropriate for applications in the pharmaceutical industry. Second, the work performed in pure solvents can serve as a basis for the design of applications with streams containing an API. The chapter also briefly focuses on membrane solvent extraction.

Original languageEnglish (US)
Title of host publicationChemical Engineering in the Pharmaceutical Industry
Publisherwiley
Pages733-750
Number of pages18
ISBN (Electronic)9781119600800
ISBN (Print)9781119285496
DOIs
StatePublished - Apr 13 2019

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Chemical Engineering(all)

Keywords

  • Active pharmaceutical ingredient processing
  • Dehydration
  • Membrane solvent extraction
  • Membrane technologies
  • Organic solvent nanofiltration
  • Pervaporation
  • Pharmaceutical industry

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