Abstract
There have been limited applications of membrane technologies in the pharmaceutical industry during active pharmaceutical ingredient (API) processing in the presence of organic solvents. The membrane technologies that are being used and/or explored in a more than cursory fashion in pharmaceutical processing are pervaporation and organic solvent nanofiltration. The majority of potential pervaporation applications in the pharmaceutical industry are related to dehydration of pharmaceutical streams. This chapter examines in more detail the work that has been performed up to now in the dehydration of organic solvents with ceramic membranes for two reasons. First, ceramic membranes are considered the most appropriate for applications in the pharmaceutical industry. Second, the work performed in pure solvents can serve as a basis for the design of applications with streams containing an API. The chapter also briefly focuses on membrane solvent extraction.
Original language | English (US) |
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Title of host publication | Chemical Engineering in the Pharmaceutical Industry |
Publisher | wiley |
Pages | 733-750 |
Number of pages | 18 |
ISBN (Electronic) | 9781119600800 |
ISBN (Print) | 9781119285496 |
DOIs | |
State | Published - Apr 13 2019 |
All Science Journal Classification (ASJC) codes
- General Engineering
- General Chemical Engineering
Keywords
- Active pharmaceutical ingredient processing
- Dehydration
- Membrane solvent extraction
- Membrane technologies
- Organic solvent nanofiltration
- Pervaporation
- Pharmaceutical industry