TY - JOUR
T1 - Mesenchymal stem cells combined with biphasic calcium phosphate ceramics promote bone regeneration
AU - Livingston, T. L.
AU - Gordon, S.
AU - Archambault, M.
AU - Kadiyala, S.
AU - Mcintosh, K.
AU - Smith, A.
AU - Peter, S. J.
N1 - Funding Information:
The authors thank Jerry Skwarek for his histological expertise and Heather Spencer, Randell Young, and Jim Cole for their contributions in animal handling and surgical procedures. Lastly, the authors thank Mohammad ElKalay for his assistance in completing the early experiments described. This work was partially sponsored through generous grants from National Institutes of Health and the National Institutes of Standards and Technology.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - The reconstruction and repair of large bone defects, resulting from trauma, cancer or metabolic disorders, is a major clinical challenge in orthopaedics. Clinically available biological and synthetic grafts have clear limitations that necessitate the development of new graft materials and/or strategies. Human mesenchymal stem cells (MSCs), obtained from the adult bone marrow, are multipotent cells capable of differentiating into various mesenchymal tissues. Of particular interest is the ability of these cells to differentiate into osteoblasts, or bone-forming cells. At Osiris, we have extensively characterized MSCs and have demonstrated MSCs can induce bone repair when implanted in vivo in combination with a biphasic calcium phosphate, specifically hydroxyapatite/tricalcium phosphate. This article reviews previous and current studies utilizing mesenchymal stem cells and biphasic calcium phosphates in bone repair.
AB - The reconstruction and repair of large bone defects, resulting from trauma, cancer or metabolic disorders, is a major clinical challenge in orthopaedics. Clinically available biological and synthetic grafts have clear limitations that necessitate the development of new graft materials and/or strategies. Human mesenchymal stem cells (MSCs), obtained from the adult bone marrow, are multipotent cells capable of differentiating into various mesenchymal tissues. Of particular interest is the ability of these cells to differentiate into osteoblasts, or bone-forming cells. At Osiris, we have extensively characterized MSCs and have demonstrated MSCs can induce bone repair when implanted in vivo in combination with a biphasic calcium phosphate, specifically hydroxyapatite/tricalcium phosphate. This article reviews previous and current studies utilizing mesenchymal stem cells and biphasic calcium phosphates in bone repair.
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U2 - 10.1023/A:1022824505404
DO - 10.1023/A:1022824505404
M3 - Review article
C2 - 15348466
AN - SCOPUS:0037354609
SN - 0957-4530
VL - 14
SP - 211
EP - 218
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 3
ER -