TY - JOUR
T1 - Mesenchymal stem cells for bone repair
T2 - Preclinical studies and potential orthopedic applications
AU - Arinzeh, Treena Livingston
PY - 2005/12
Y1 - 2005/12
N2 - Mesenchymal stem cell-based bone regeneration has been demonstrated in various animal models. Preclinical models described in this review primarily focused on the repair of segmental defects. Other orthopedic applications, such as spine fusion and craniotomy defects, are also of interest for the delivery of MSCs. Although preclinical and clinical data for other applications demonstrate safety and efficacy of MSCs, many issues still surround the mechanism of action. Concerns exist regarding the therapeutic efficacy of transplanted cells and the mechanism of engraftment, homing, and in vivo differentiation. Long-term safety studies are also still needed. Scale-up of stem cell culture, storage, and distribution will also be an issue when a greater demand for stem cell therapy arises.
AB - Mesenchymal stem cell-based bone regeneration has been demonstrated in various animal models. Preclinical models described in this review primarily focused on the repair of segmental defects. Other orthopedic applications, such as spine fusion and craniotomy defects, are also of interest for the delivery of MSCs. Although preclinical and clinical data for other applications demonstrate safety and efficacy of MSCs, many issues still surround the mechanism of action. Concerns exist regarding the therapeutic efficacy of transplanted cells and the mechanism of engraftment, homing, and in vivo differentiation. Long-term safety studies are also still needed. Scale-up of stem cell culture, storage, and distribution will also be an issue when a greater demand for stem cell therapy arises.
UR - http://www.scopus.com/inward/record.url?scp=27744581074&partnerID=8YFLogxK
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U2 - 10.1016/j.fcl.2005.06.004
DO - 10.1016/j.fcl.2005.06.004
M3 - Review article
C2 - 16297825
AN - SCOPUS:27744581074
SN - 1083-7515
VL - 10
SP - 651
EP - 665
JO - Foot and Ankle Clinics
JF - Foot and Ankle Clinics
IS - 4
ER -