Microfluidics for High Throughput Screening of Biological Agents and Therapeutics

Anant Bhusal; Swaprakash Yogeshwaran; Hossein Goodarzi Hosseinabadi; Berivan Cecen; Amir K. Miri

doi:10.1007/s44174-024-00169-1

Microfluidics for High Throughput Screening of Biological Agents and Therapeutics

Anant Bhusal, Swaprakash Yogeshwaran, Hossein Goodarzi Hosseinabadi, Berivan Cecen, Amir K. Miri

Bio-Medical Engineering

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Microfluidic devices have been widely used for gene analysis, immunoassays, organ-on-chip technology, cell engineering, and disease modeling. Their integration into high throughput screening (HTS) platforms has led to large-scale testing of various biological and chemical agents. This brief review discusses existing microfluidic HTS modalities, including the droplet mode, the perfusion mode, and the array-based platforms in active or passive designs, by exploring their fabrication methods and key design features. The main compartments are discussed, and the future trajectories of microfluidic HTS platforms, particularly in drug screening, are explained in detail. This review aims to serve as a guide for bioengineers and clinicians, offering insights to advance the development of the microfluidic toolboxes utilized in drug screening efforts.

Original language	English (US)
Pages (from-to)	93-107
Number of pages	15
Journal	Biomedical Materials and Devices
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s44174-024-00169-1
State	Published - Mar 2025

All Science Journal Classification (ASJC) codes

Chemistry (miscellaneous)
Engineering (miscellaneous)
Biomedical Engineering
Biomaterials

Keywords

3D printing
High throughput screening
Hydrogels
Microfluidics

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10.1007/s44174-024-00169-1

Cite this

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abstract = "Microfluidic devices have been widely used for gene analysis, immunoassays, organ-on-chip technology, cell engineering, and disease modeling. Their integration into high throughput screening (HTS) platforms has led to large-scale testing of various biological and chemical agents. This brief review discusses existing microfluidic HTS modalities, including the droplet mode, the perfusion mode, and the array-based platforms in active or passive designs, by exploring their fabrication methods and key design features. The main compartments are discussed, and the future trajectories of microfluidic HTS platforms, particularly in drug screening, are explained in detail. This review aims to serve as a guide for bioengineers and clinicians, offering insights to advance the development of the microfluidic toolboxes utilized in drug screening efforts.",

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AU - Bhusal, Anant

AU - Yogeshwaran, Swaprakash

AU - Goodarzi Hosseinabadi, Hossein

AU - Cecen, Berivan

AU - Miri, Amir K.

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2025/3

Y1 - 2025/3

N2 - Microfluidic devices have been widely used for gene analysis, immunoassays, organ-on-chip technology, cell engineering, and disease modeling. Their integration into high throughput screening (HTS) platforms has led to large-scale testing of various biological and chemical agents. This brief review discusses existing microfluidic HTS modalities, including the droplet mode, the perfusion mode, and the array-based platforms in active or passive designs, by exploring their fabrication methods and key design features. The main compartments are discussed, and the future trajectories of microfluidic HTS platforms, particularly in drug screening, are explained in detail. This review aims to serve as a guide for bioengineers and clinicians, offering insights to advance the development of the microfluidic toolboxes utilized in drug screening efforts.

AB - Microfluidic devices have been widely used for gene analysis, immunoassays, organ-on-chip technology, cell engineering, and disease modeling. Their integration into high throughput screening (HTS) platforms has led to large-scale testing of various biological and chemical agents. This brief review discusses existing microfluidic HTS modalities, including the droplet mode, the perfusion mode, and the array-based platforms in active or passive designs, by exploring their fabrication methods and key design features. The main compartments are discussed, and the future trajectories of microfluidic HTS platforms, particularly in drug screening, are explained in detail. This review aims to serve as a guide for bioengineers and clinicians, offering insights to advance the development of the microfluidic toolboxes utilized in drug screening efforts.

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KW - High throughput screening

KW - Hydrogels

KW - Microfluidics

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Microfluidics for High Throughput Screening of Biological Agents and Therapeutics

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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