Microstructural and mechanical characterization of scarred vocal folds

Hossein K. Heris, Amir K. Miri, Nageswara R. Ghattamaneni, Nicole Y.K. Li, Susan L. Thibeault, Paul W. Wiseman, Luc Mongeau

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The goal of this study was to characterize the vocal folds microstructure and elasticity using nonlinear laser scanning microscopy and atomic force microscopy-based indentation, respectively. As a pilot study, the vocal folds of fourteen rats were unilaterally injured by full removal of lamina propria; the uninjured folds of the same animals served as controls. The area fraction of collagen fibrils was found to be greater in scarred tissues two months after injury than the uninjured controls. A novel mathematical model was also proposed to relate collagen concentration and tissue bulk modulus. This work presents a first step towards systematic investigation of microstructural and mechanical characteristics in scarred vocal fold tissue.

Original languageEnglish (US)
Pages (from-to)708-711
Number of pages4
JournalJournal of Biomechanics
Issue number4
StatePublished - Feb 26 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Rehabilitation
  • Biomedical Engineering
  • Orthopedics and Sports Medicine


  • Atomic force microscopy
  • Scarring
  • Second harmonic generation
  • Vocal fold


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