Microstructural and mechanical characterization of scarred vocal folds

Hossein K. Heris; Amir K. Miri; Nageswara R. Ghattamaneni; Nicole Y.K. Li; Susan L. Thibeault; Paul W. Wiseman; Luc Mongeau

doi:10.1016/j.jbiomech.2015.01.014

Microstructural and mechanical characterization of scarred vocal folds

Hossein K. Heris, Amir K. Miri, Nageswara R. Ghattamaneni, Nicole Y.K. Li, Susan L. Thibeault, Paul W. Wiseman, Luc Mongeau

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The goal of this study was to characterize the vocal folds microstructure and elasticity using nonlinear laser scanning microscopy and atomic force microscopy-based indentation, respectively. As a pilot study, the vocal folds of fourteen rats were unilaterally injured by full removal of lamina propria; the uninjured folds of the same animals served as controls. The area fraction of collagen fibrils was found to be greater in scarred tissues two months after injury than the uninjured controls. A novel mathematical model was also proposed to relate collagen concentration and tissue bulk modulus. This work presents a first step towards systematic investigation of microstructural and mechanical characteristics in scarred vocal fold tissue.

Original language	English (US)
Pages (from-to)	708-711
Number of pages	4
Journal	Journal of Biomechanics
Volume	48
Issue number	4
DOIs	https://doi.org/10.1016/j.jbiomech.2015.01.014
State	Published - Feb 26 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biomedical Engineering
Orthopedics and Sports Medicine
Rehabilitation

Keywords

Atomic force microscopy
Scarring
Second harmonic generation
Vocal fold

Access to Document

10.1016/j.jbiomech.2015.01.014

Cite this

@article{443410c152f14779a075b7b41179613f,

title = "Microstructural and mechanical characterization of scarred vocal folds",

abstract = "The goal of this study was to characterize the vocal folds microstructure and elasticity using nonlinear laser scanning microscopy and atomic force microscopy-based indentation, respectively. As a pilot study, the vocal folds of fourteen rats were unilaterally injured by full removal of lamina propria; the uninjured folds of the same animals served as controls. The area fraction of collagen fibrils was found to be greater in scarred tissues two months after injury than the uninjured controls. A novel mathematical model was also proposed to relate collagen concentration and tissue bulk modulus. This work presents a first step towards systematic investigation of microstructural and mechanical characteristics in scarred vocal fold tissue.",

keywords = "Atomic force microscopy, Scarring, Second harmonic generation, Vocal fold",

author = "Heris, {Hossein K.} and Miri, {Amir K.} and Ghattamaneni, {Nageswara R.} and Li, {Nicole Y.K.} and Thibeault, {Susan L.} and Wiseman, {Paul W.} and Luc Mongeau",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = feb,

day = "26",

doi = "10.1016/j.jbiomech.2015.01.014",

language = "English (US)",

volume = "48",

pages = "708--711",

journal = "Journal of Biomechanics",

issn = "0021-9290",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Microstructural and mechanical characterization of scarred vocal folds

AU - Heris, Hossein K.

AU - Miri, Amir K.

AU - Ghattamaneni, Nageswara R.

AU - Li, Nicole Y.K.

AU - Thibeault, Susan L.

AU - Wiseman, Paul W.

AU - Mongeau, Luc

PY - 2015/2/26

Y1 - 2015/2/26

N2 - The goal of this study was to characterize the vocal folds microstructure and elasticity using nonlinear laser scanning microscopy and atomic force microscopy-based indentation, respectively. As a pilot study, the vocal folds of fourteen rats were unilaterally injured by full removal of lamina propria; the uninjured folds of the same animals served as controls. The area fraction of collagen fibrils was found to be greater in scarred tissues two months after injury than the uninjured controls. A novel mathematical model was also proposed to relate collagen concentration and tissue bulk modulus. This work presents a first step towards systematic investigation of microstructural and mechanical characteristics in scarred vocal fold tissue.

AB - The goal of this study was to characterize the vocal folds microstructure and elasticity using nonlinear laser scanning microscopy and atomic force microscopy-based indentation, respectively. As a pilot study, the vocal folds of fourteen rats were unilaterally injured by full removal of lamina propria; the uninjured folds of the same animals served as controls. The area fraction of collagen fibrils was found to be greater in scarred tissues two months after injury than the uninjured controls. A novel mathematical model was also proposed to relate collagen concentration and tissue bulk modulus. This work presents a first step towards systematic investigation of microstructural and mechanical characteristics in scarred vocal fold tissue.

KW - Atomic force microscopy

KW - Scarring

KW - Second harmonic generation

KW - Vocal fold

UR - http://www.scopus.com/inward/record.url?scp=84922778199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922778199&partnerID=8YFLogxK

U2 - 10.1016/j.jbiomech.2015.01.014

DO - 10.1016/j.jbiomech.2015.01.014

M3 - Article

C2 - 25648495

AN - SCOPUS:84922778199

SN - 0021-9290

VL - 48

SP - 708

EP - 711

JO - Journal of Biomechanics

JF - Journal of Biomechanics

IS - 4

ER -

Microstructural and mechanical characterization of scarred vocal folds

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this