Miscibility characterization of indomethacin and Eudragit® E PO by rheological and thermal analysis

Huiju Liu, Herman Suwardie, Xueyan Zhang, Peng Wang, Costas G. Gogos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The miscibility between drug indomethacin and excipient Eudragit* E PO were extensively characterized by rheological and thermal analysis. The evolution of glass transition temperature and activation energy with indomethacin concentration indicates the existence of overall positive deviation which represents anti-plasticization effect. The rheological analysis is in agreement with the thermal analysis, and both methods indicate that the miscibility between them is very good for indomethacin concentrations up to 60-70%.

Original languageEnglish (US)
Title of host publication70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012
Pages71-75
Number of pages5
StatePublished - 2012
Event70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012 - Orlando, FL, United States
Duration: Apr 2 2012Apr 4 2012

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume1

Other

Other70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012
CountryUnited States
CityOrlando, FL
Period4/2/124/4/12

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics

Keywords

  • E PO
  • Eudragit®
  • Indomethacin
  • Miscibility
  • Solid dispersion

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