Computational fluid dynamics simulations are conducted to characterize the spatial and temporal characteristics of the turbulent flow fields inside Francis turbine operating at the design and partial load regimes. High-fidelity large eddy simulations turbulence model is applied to investigate the flow-induced vibrations in the draft tube of the unit. The water injection at 4% rate from the runner cone is implemented to control the flow-induced pressure fluctuations. The simulations are conducted at the turbine design point and two partial load operations with and without water injection. It has been demonstrated that the water injection has a profound influence in the turbulent flow structure and the pressure field inside the draft tube at the partial load operating conditions. To evaluate the effectiveness of the water injection techniques in mitigating flow-induced fluctuations, the probes at various locations along the wall of the draft tube are used to monitor the pressure signals. It appears to be a reduction in the level of pressure fluctuations by the water injection at both partial load operating regimes. However, we could not draw a firm conclusion about the level of mitigation of flow-induced vibrations. Simulations should be carried out for much longer flow time. Water injection hardly influenced the unit power generation. Hence water injection can be employed effectively without a major liability on the power generation.