Mitochondrial DNA Mutations and Aging

Rebecca Gordon, Sara C. Zapico

Research output: Chapter in Book/Report/Conference proceedingChapter


Bratic and Larsson (2013) proposed the “mitochondrial theory of aging”, which is based on the following observations: "(1) mitochondrial ROS production increases with age because of a decline in mitochondrial function; (2) activity of several free radical-scavenging enzymes declines with age; (3) mutations of mitochondrial DNA (mtDNA) accumulate during aging; (4) a vicious cycle occurs because mtDNA mutations impair Electron Transport Chain function, increasing ROS production and accumulating oxidative damage to proteins, lipids and DNA.” This theory builds on earlier studies which focused on the role of mitochondrial mutations and aging.

Original languageEnglish (US)
Title of host publicationMechanisms Linking Aging, Diseases and Biological Age Estimation
PublisherCRC Press
Number of pages8
ISBN (Electronic)9781498709705
ISBN (Print)9781498709699
StatePublished - Jan 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Social Sciences
  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


  • Aging
  • Brain
  • Deletions
  • Free radical theory of aging
  • Haplogroups
  • Heart
  • Heteroplasmy
  • Mitochondrial DNA mutations (mtDNA)
  • Mitochondrial theory of aging
  • Muscle
  • Point mutations
  • Single cell


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