Mitochondrial DNA Mutations and Aging

Rebecca Gordon; Sara C. Zapico

doi:10.1201/9781315371382

Mitochondrial DNA Mutations and Aging

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Bratic and Larsson (2013) proposed the “mitochondrial theory of aging”, which is based on the following observations: "(1) mitochondrial ROS production increases with age because of a decline in mitochondrial function; (2) activity of several free radical-scavenging enzymes declines with age; (3) mutations of mitochondrial DNA (mtDNA) accumulate during aging; (4) a vicious cycle occurs because mtDNA mutations impair Electron Transport Chain function, increasing ROS production and accumulating oxidative damage to proteins, lipids and DNA.” This theory builds on earlier studies which focused on the role of mitochondrial mutations and aging.

Original language	English (US)
Title of host publication	Mechanisms Linking Aging, Diseases and Biological Age Estimation
Publisher	CRC Press
Pages	193-200
Number of pages	8
ISBN (Electronic)	9781498709705
ISBN (Print)	9781498709699
DOIs	https://doi.org/10.1201/9781315371382
State	Published - Jan 1 2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Social Sciences
General Medicine
General Biochemistry, Genetics and Molecular Biology

Keywords

Aging
Brain
Deletions
Free radical theory of aging
Haplogroups
Heart
Heteroplasmy
Mitochondrial DNA mutations (mtDNA)
Mitochondrial theory of aging
Muscle
Point mutations
Single cell

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10.1201/9781315371382

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abstract = "Bratic and Larsson (2013) proposed the “mitochondrial theory of aging”, which is based on the following observations: {"}(1) mitochondrial ROS production increases with age because of a decline in mitochondrial function; (2) activity of several free radical-scavenging enzymes declines with age; (3) mutations of mitochondrial DNA (mtDNA) accumulate during aging; (4) a vicious cycle occurs because mtDNA mutations impair Electron Transport Chain function, increasing ROS production and accumulating oxidative damage to proteins, lipids and DNA.” This theory builds on earlier studies which focused on the role of mitochondrial mutations and aging.",

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doi = "10.1201/9781315371382",

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AU - Gordon, Rebecca

AU - Zapico, Sara C.

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N2 - Bratic and Larsson (2013) proposed the “mitochondrial theory of aging”, which is based on the following observations: "(1) mitochondrial ROS production increases with age because of a decline in mitochondrial function; (2) activity of several free radical-scavenging enzymes declines with age; (3) mutations of mitochondrial DNA (mtDNA) accumulate during aging; (4) a vicious cycle occurs because mtDNA mutations impair Electron Transport Chain function, increasing ROS production and accumulating oxidative damage to proteins, lipids and DNA.” This theory builds on earlier studies which focused on the role of mitochondrial mutations and aging.

AB - Bratic and Larsson (2013) proposed the “mitochondrial theory of aging”, which is based on the following observations: "(1) mitochondrial ROS production increases with age because of a decline in mitochondrial function; (2) activity of several free radical-scavenging enzymes declines with age; (3) mutations of mitochondrial DNA (mtDNA) accumulate during aging; (4) a vicious cycle occurs because mtDNA mutations impair Electron Transport Chain function, increasing ROS production and accumulating oxidative damage to proteins, lipids and DNA.” This theory builds on earlier studies which focused on the role of mitochondrial mutations and aging.

KW - Aging

KW - Brain

KW - Deletions

KW - Free radical theory of aging

KW - Haplogroups

KW - Heart

KW - Heteroplasmy

KW - Mitochondrial DNA mutations (mtDNA)

KW - Mitochondrial theory of aging

KW - Muscle

KW - Point mutations

KW - Single cell

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BT - Mechanisms Linking Aging, Diseases and Biological Age Estimation

PB - CRC Press

ER -

Mitochondrial DNA Mutations and Aging

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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