Modeling and design of transdermal drug delivery patches containing an external heating device

Kwang Seok Kim, Laurent Simon

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Process modeling and design concepts were implemented to aid in the manufacturing of heat-enhanced transdermal drug-delivery systems. The simulated prototype consists of a corticosterone-loaded polymer patch applied to the skin and connected to a heating device in which an exothermic reaction occurs. To achieve a desired transdermal flux of 1.2×10-5mg/cm2h, this contribution focuses on the influences of the (1) initial reaction rate (-rA0), (2) mass of filler material in the device (m), (3) initial concentration (C0) of medicament in the patch and (4) overall heat transfer coefficient (U). A regression technique yielded the following results: -rA0=3.000×10-2kg/m3s, m=1.251×10-8kg, U=6.124×10J/m2Ks and C0=1.966×10-1kg/m3. When m was fixed at 12.5g, the optimum design required the following specifications: rA0=2.765×10-2kg/m3s, U=1.402×103J/m2Ks and C0=1.941×10-1kg/m3. The priority (Si) of the input factors (i) in reaching the target delivery rate is: SC0>S-rA0>Sm>SU.

Original languageEnglish (US)
Pages (from-to)1152-1163
Number of pages12
JournalComputers and Chemical Engineering
Volume35
Issue number6
DOIs
StatePublished - Jun 9 2011

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Computer Science Applications

Keywords

  • Heat
  • Mathematical model
  • Nonlinear pharmacokinetics
  • Optimization
  • Process design
  • Transdermal

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