Modeling of macromolecule transfer in microvessel

Summary form only given. A one-dimensional unsteady-state model developed to describe the transfer of macromolecules across a microvascular wall and into the interstitial space is discussed. The model accounts for both molecular diffusion and convective transfer through the microvascular wall as well as in the interstitial space. The resulting partial-differential equations are coupled by the two boundary conditions at the wall-interstitial-space interface representing the equilibrium at the interface and the continuity of the mass flux leaving the microvascular wall and entering the interstitial space. A solution to the equations and an analytical expression for the total amount of mass which has accumulated in a portion of the interstitial space at any given time are also discussed.