Modeling of muscle atrophy and exercise induced hypertrophy

Xianlian Zhou, Paulien E. Roos, Xinyu Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A better understanding of the time course of changes in muscle performance in response to spaceflight and exercise is required to maintain sufficient muscle function for long duration spaceflight. This paper presents a semi-empirical and dynamic muscle adaptation (atrophy and hypertrophy) model driven by a muscle activation profile that is directly related to muscle exercise intensity and exercise-rest cycles. The effect of muscle adaptation is described by two phenomenological parameters (s; τ), where s is related to the physiological limit of adaption and τ governs rate of adaptation. Both s and τ mathematically depend on the instantaneous muscle activation level (a). The model is calibrated against selected atrophy and hypertrophy experimental data. It was demonstrated that: (1) the model is capable to handle muscle atrophy and hypertrophy in a unified setting; (2) the model can be used for prediction of muscle atrophy during a 6-month spaceflight under two different exercise regimes.

Original languageEnglish (US)
Title of host publicationAdvances in Human Factors in Simulation and Modeling - Proceedings of the AHFE 2017 International Conference on Human Factors in Simulation and Modeling, 2017
EditorsDaniel N. Cassenti
PublisherSpringer Verlag
Pages116-127
Number of pages12
ISBN (Print)9783319605906
DOIs
StatePublished - Jan 1 2018
Externally publishedYes
EventAHFE 2017 International Conference on Human Factors in Simulation and Modeling, 2017 - Los Angeles, United States
Duration: Jul 17 2017Jul 21 2017

Publication series

NameAdvances in Intelligent Systems and Computing
Volume591
ISSN (Print)2194-5357

Conference

ConferenceAHFE 2017 International Conference on Human Factors in Simulation and Modeling, 2017
CountryUnited States
CityLos Angeles
Period7/17/177/21/17

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Computer Science(all)

Keywords

  • Exercise
  • Muscle activation
  • Muscle atrophy
  • Muscle hypertrophy
  • Spaceflight

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