Modelling the in-vitro dissolution and release of sumatriptan succinate from polyvinylpyrrolidone-based microneedles

P. Ronnander, L. Simon, H. Spilgies, A. Koch

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A mathematical model was developed to predict the transport of sumatriptan molecules across the skin followed by absorption into the bloodstream. The drug was encapsulated in dissolving polyvinylpyrrolidone-based microneedles shaped in the form of pyramids. Mass balance equations were derived to simulate the dissolution and transport of the pharmaceutical ingredient. The theoretical framework made it possible to assess and predict the effects of key parameters on the release profile. The skin concentration increased with the loading dose and the height of the microneedle. An inverse relationship was noted between the amount of drug released in the dermal layer and the pitch width. These results were validated with in-vitro diffusion studies previously conducted using Göttingen minipig skin. The new mathematical approach successfully explained the in-vitro permeation of three different sumatriptan-containing formulations.

Original languageEnglish (US)
Pages (from-to)54-63
Number of pages10
JournalEuropean Journal of Pharmaceutical Sciences
Volume125
DOIs
StatePublished - Dec 1 2018

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Controlled release
  • Dissolution
  • Dissolving microneedles
  • Göttingen minipig
  • Modelling
  • Polyvinylpyrrolidone
  • Sumatriptan succinate

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