TY - JOUR
T1 - Monitoring bound HA1(H1N1) and HA1(H5N1) on freely suspended graphene over plasmonic platforms with infrared spectroscopy
AU - Banerjee, Amrita
AU - Chakraborty, Sumit
AU - Altan-Bonnet, Nihal
AU - Grebel, Haim
N1 - Funding Information:
We wish to acknowledge the Consortium for Functional Glycomics Grant number GM62116 for providing us with the tri-saccharides. We thank David F. Smith, Emory University, School of Medicine and James H. Prestegard, Complex Carbohydrate Research Center, University of Georgia for useful discussions. We also thank Samarth Trivedi of NJIT for taking the SEM pictures. NAB was funded by NIH 5R01AI091985-03.
PY - 2013
Y1 - 2013
N2 - Infrared (IR) spectroscopy provides fingerprinting of the energy and orientation of molecular bonds. The IR signals are generally weak and require amplification. Here we present a new plasmonic platform, made of freely suspended graphene, which was coating periodic metal structures. Only monolayer thick films were needed for a fast signal recording. We demonstrated unique IR absorption signals of bound proteins: these were the hemagglutinin area (HA1) of swine influenza (H1N1) and the avian influenza (H5N1) viruses bound to their respective tri-saccharides ligand receptors. The simplicity and sensitivity of such approach may find applications in fast monitoring of binding events.
AB - Infrared (IR) spectroscopy provides fingerprinting of the energy and orientation of molecular bonds. The IR signals are generally weak and require amplification. Here we present a new plasmonic platform, made of freely suspended graphene, which was coating periodic metal structures. Only monolayer thick films were needed for a fast signal recording. We demonstrated unique IR absorption signals of bound proteins: these were the hemagglutinin area (HA1) of swine influenza (H1N1) and the avian influenza (H5N1) viruses bound to their respective tri-saccharides ligand receptors. The simplicity and sensitivity of such approach may find applications in fast monitoring of binding events.
UR - http://www.scopus.com/inward/record.url?scp=84883257702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883257702&partnerID=8YFLogxK
U2 - 10.1016/j.cplett.2013.07.010
DO - 10.1016/j.cplett.2013.07.010
M3 - Article
AN - SCOPUS:84883257702
SN - 0009-2614
VL - 582
SP - 134
EP - 140
JO - Chemical Physics Letters
JF - Chemical Physics Letters
ER -