Monitoring bound HA1(H1N1) and HA1(H5N1) on freely suspended graphene over plasmonic platforms with infrared spectroscopy

Amrita Banerjee; Sumit Chakraborty; Nihal Altan-Bonnet; Haim Grebel

doi:10.1016/j.cplett.2013.07.010

Monitoring bound HA1(H1N1) and HA1(H5N1) on freely suspended graphene over plasmonic platforms with infrared spectroscopy

Amrita Banerjee
, Sumit Chakraborty
, Nihal Altan-Bonnet
, Haim Grebel

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Infrared (IR) spectroscopy provides fingerprinting of the energy and orientation of molecular bonds. The IR signals are generally weak and require amplification. Here we present a new plasmonic platform, made of freely suspended graphene, which was coating periodic metal structures. Only monolayer thick films were needed for a fast signal recording. We demonstrated unique IR absorption signals of bound proteins: these were the hemagglutinin area (HA1) of swine influenza (H1N1) and the avian influenza (H5N1) viruses bound to their respective tri-saccharides ligand receptors. The simplicity and sensitivity of such approach may find applications in fast monitoring of binding events.

Original language	English (US)
Pages (from-to)	134-140
Number of pages	7
Journal	Chemical Physics Letters
Volume	582
DOIs	https://doi.org/10.1016/j.cplett.2013.07.010
State	Published - 2013

All Science Journal Classification (ASJC) codes

General Physics and Astronomy
Physical and Theoretical Chemistry

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10.1016/j.cplett.2013.07.010

Cite this

@article{01c6739ad54a427c9f75713d02d1dd7e,

title = "Monitoring bound HA1(H1N1) and HA1(H5N1) on freely suspended graphene over plasmonic platforms with infrared spectroscopy",

abstract = "Infrared (IR) spectroscopy provides fingerprinting of the energy and orientation of molecular bonds. The IR signals are generally weak and require amplification. Here we present a new plasmonic platform, made of freely suspended graphene, which was coating periodic metal structures. Only monolayer thick films were needed for a fast signal recording. We demonstrated unique IR absorption signals of bound proteins: these were the hemagglutinin area (HA1) of swine influenza (H1N1) and the avian influenza (H5N1) viruses bound to their respective tri-saccharides ligand receptors. The simplicity and sensitivity of such approach may find applications in fast monitoring of binding events.",

author = "Amrita Banerjee and Sumit Chakraborty and Nihal Altan-Bonnet and Haim Grebel",

note = "Funding Information: We wish to acknowledge the Consortium for Functional Glycomics Grant number GM62116 for providing us with the tri-saccharides. We thank David F. Smith, Emory University, School of Medicine and James H. Prestegard, Complex Carbohydrate Research Center, University of Georgia for useful discussions. We also thank Samarth Trivedi of NJIT for taking the SEM pictures. NAB was funded by NIH 5R01AI091985-03. ",

year = "2013",

doi = "10.1016/j.cplett.2013.07.010",

language = "English (US)",

volume = "582",

pages = "134--140",

journal = "Chemical Physics Letters",

issn = "0009-2614",

publisher = "Elsevier B.V.",

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T1 - Monitoring bound HA1(H1N1) and HA1(H5N1) on freely suspended graphene over plasmonic platforms with infrared spectroscopy

AU - Banerjee, Amrita

AU - Chakraborty, Sumit

AU - Altan-Bonnet, Nihal

AU - Grebel, Haim

N1 - Funding Information: We wish to acknowledge the Consortium for Functional Glycomics Grant number GM62116 for providing us with the tri-saccharides. We thank David F. Smith, Emory University, School of Medicine and James H. Prestegard, Complex Carbohydrate Research Center, University of Georgia for useful discussions. We also thank Samarth Trivedi of NJIT for taking the SEM pictures. NAB was funded by NIH 5R01AI091985-03.

PY - 2013

Y1 - 2013

N2 - Infrared (IR) spectroscopy provides fingerprinting of the energy and orientation of molecular bonds. The IR signals are generally weak and require amplification. Here we present a new plasmonic platform, made of freely suspended graphene, which was coating periodic metal structures. Only monolayer thick films were needed for a fast signal recording. We demonstrated unique IR absorption signals of bound proteins: these were the hemagglutinin area (HA1) of swine influenza (H1N1) and the avian influenza (H5N1) viruses bound to their respective tri-saccharides ligand receptors. The simplicity and sensitivity of such approach may find applications in fast monitoring of binding events.

AB - Infrared (IR) spectroscopy provides fingerprinting of the energy and orientation of molecular bonds. The IR signals are generally weak and require amplification. Here we present a new plasmonic platform, made of freely suspended graphene, which was coating periodic metal structures. Only monolayer thick films were needed for a fast signal recording. We demonstrated unique IR absorption signals of bound proteins: these were the hemagglutinin area (HA1) of swine influenza (H1N1) and the avian influenza (H5N1) viruses bound to their respective tri-saccharides ligand receptors. The simplicity and sensitivity of such approach may find applications in fast monitoring of binding events.

UR - https://www.scopus.com/pages/publications/84883257702

UR - https://www.scopus.com/pages/publications/84883257702#tab=citedBy

U2 - 10.1016/j.cplett.2013.07.010

DO - 10.1016/j.cplett.2013.07.010

M3 - Article

AN - SCOPUS:84883257702

SN - 0009-2614

VL - 582

SP - 134

EP - 140

JO - Chemical Physics Letters

JF - Chemical Physics Letters

ER -

Monitoring bound HA1(H1N1) and HA1(H5N1) on freely suspended graphene over plasmonic platforms with infrared spectroscopy

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