Monte Carlo simulation of light-tissue interaction: Three-dimensional simulation for trans-illumination-based imaging of skin lesions

Sachin V. Patwardhan, Atam P. Dhawan, Patricia A. Relue

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Three-dimensional, voxel-based, and wavelength-dependent skin lesion models are developed and simulated using Monte Carlo techniques. The optical geometry of the Nevoscope with trans-illumination is used in the simulations for characterizing the lesion thickness. Based on the correlation analysis between the lesion thickness and the diffuse reflectance, optical wavelengths are selected for multispectral imaging of skin lesions using the Nevoscope. Tissue optical properties reported by various researchers are compiled together to form a voxel library. Tissue models used in the simulations are developed using the voxel library which offers flexibility in updating the optical properties and adding new media types into the models independent of the Monte Carlo simulation code.

Original languageEnglish (US)
Pages (from-to)1227-1236
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Volume52
Issue number7
DOIs
StatePublished - Jul 2005

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Keywords

  • Correlation analysis
  • Multispectral imaging
  • Nevoscope
  • Skin lesion models
  • Voxel-based Monte Carlo simulation

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