MoS2-enabled dual-mode optoelectronic biosensor using a water soluble variant of µ-opioid receptor for opioid peptide detection

Chawina De-Eknamkul, Xingwang Zhang, Meng Qiang Zhao, Wenzhuo Huang, Renyu Liu, A. T.Charlie Johnson, Ertugrul Cubukcu

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Owing to their unique electrical and optical properties, two-dimensional transition metal dichalcogenides have been extensively studied for their potential applications in biosensing. However, simultaneous utilization of both optical and electrical properties has been overlooked, yet it can offer enhanced accuracy and detection versitility. Here, we demonstrate a dual-mode optoelectronic biosensor based on monolayer molybdenum disulfide (MoS2) capable of producing simultaneous electrical and optical readouts of biomolecular signals. On a single platform, the biosensor exhibits a tunable photonic Fano-type optical resonance while also functioning as a field-effect transistor (FET) based on a optically transparent gate electrode. Furthermore, chemical vapor deposition grown MoS2 provides a clean surface for direct immobilization of a water-soluble variant of the μ-opioid receptor (wsMOR), via a nickel ion-mediated linker chemistry. We utilize a synthetic opioid peptide to show the operation of the electronic and optical sensing modes. The responses of both modes exhibit a similar trend with dynamic ranges of four orders of magnitude and detection limits of <1 nM. Our work explores the potential of a versatile multimodal sensing platform enabled by monolayer MoS2, since the integration of electrical and optical sensors on the same chip can offer flexibility in read-out and improve the accuracy in detection of low concentration targets.

Original languageEnglish (US)
Article number014004
Journal2D Materials
Issue number1
StatePublished - 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


  • field-effect transistor
  • molybdenum disulfide
  • mu-opioid receptor
  • multimodal biosensor
  • photonic crystal
  • transition metal dichalcogenides


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