Multi-organs-on-chips for testing small-molecule drugs: Challenges and perspectives

Berivan Cecen; Christina Karavasili; Mubashir Nazir; Anant Bhusal; Elvan Dogan; Fatemeh Shahriyari; Sedef Tamburaci; Melda Buyukoz; Leyla Didem Kozaci; Amir K. Miri

doi:10.3390/pharmaceutics13101657

Multi-organs-on-chips for testing small-molecule drugs: Challenges and perspectives

Berivan Cecen, Christina Karavasili, Mubashir Nazir, Anant Bhusal, Elvan Dogan, Fatemeh Shahriyari, Sedef Tamburaci, Melda Buyukoz, Leyla Didem Kozaci, Amir K. Miri

Bio-Medical Engineering

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms.

Original language	English (US)
Article number	1657
Journal	Pharmaceutics
Volume	13
Issue number	10
DOIs	https://doi.org/10.3390/pharmaceutics13101657
State	Published - Oct 2021

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Keywords

High-throughput screening
Microfluidics
Multi-organ-on-a-chip
Small drugs

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10.3390/pharmaceutics13101657

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abstract = "Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms.",

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author = "Berivan Cecen and Christina Karavasili and Mubashir Nazir and Anant Bhusal and Elvan Dogan and Fatemeh Shahriyari and Sedef Tamburaci and Melda Buyukoz and Kozaci, {Leyla Didem} and Miri, {Amir K.}",

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AU - Cecen, Berivan

AU - Karavasili, Christina

AU - Nazir, Mubashir

AU - Bhusal, Anant

AU - Dogan, Elvan

AU - Shahriyari, Fatemeh

AU - Tamburaci, Sedef

AU - Buyukoz, Melda

AU - Kozaci, Leyla Didem

AU - Miri, Amir K.

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N2 - Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms.

AB - Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms.

KW - High-throughput screening

KW - Microfluidics

KW - Multi-organ-on-a-chip

KW - Small drugs

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Multi-organs-on-chips for testing small-molecule drugs: Challenges and perspectives

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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