Multimodal nanodiamond drug delivery carriers for selective targeting, imaging, and enhanced chemotherapeutic efficacy

Xue Qing Zhang; Robert Lam; Xiaoyang Xu; Edward K. Chow; Ho Joong Kim; Dean Ho

doi:10.1002/adma.201102263

Multimodal nanodiamond drug delivery carriers for selective targeting, imaging, and enhanced chemotherapeutic efficacy

Xue Qing Zhang, Robert Lam, Xiaoyang Xu, Edward K. Chow, Ho Joong Kim, Dean Ho

Research output: Contribution to journal › Article › peer-review

223 Scopus citations

Abstract

Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug-oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalent attachment of the chemotherapeutic and targeting moiety to the ND surface significantly enhanced cellular internalization and therapeutic activity

Original language	English (US)
Pages (from-to)	4770-4775
Number of pages	6
Journal	Advanced Materials
Volume	23
Issue number	41
DOIs	https://doi.org/10.1002/adma.201102263
State	Published - Nov 2 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Materials Science
Mechanics of Materials
Mechanical Engineering

Keywords

DNA
Paclitaxel
drug delivery
nanodiamonds
nanomedicine

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10.1002/adma.201102263

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abstract = "Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug-oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalent attachment of the chemotherapeutic and targeting moiety to the ND surface significantly enhanced cellular internalization and therapeutic activity",

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AU - Lam, Robert

AU - Xu, Xiaoyang

AU - Chow, Edward K.

AU - Kim, Ho Joong

AU - Ho, Dean

PY - 2011/11/2

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AB - Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug-oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalent attachment of the chemotherapeutic and targeting moiety to the ND surface significantly enhanced cellular internalization and therapeutic activity

KW - DNA

KW - Paclitaxel

KW - drug delivery

KW - nanodiamonds

KW - nanomedicine

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ER -

Multimodal nanodiamond drug delivery carriers for selective targeting, imaging, and enhanced chemotherapeutic efficacy

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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