Multimodal nanodiamond drug delivery carriers for selective targeting, imaging, and enhanced chemotherapeutic efficacy

Xue Qing Zhang, Robert Lam, Xiaoyang Xu, Edward K. Chow, Ho Joong Kim, Dean Ho

Research output: Contribution to journalArticlepeer-review

172 Scopus citations

Abstract

Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug-oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalent attachment of the chemotherapeutic and targeting moiety to the ND surface significantly enhanced cellular internalization and therapeutic activity

Original languageEnglish (US)
Pages (from-to)4770-4775
Number of pages6
JournalAdvanced Materials
Volume23
Issue number41
DOIs
StatePublished - Nov 2 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Keywords

  • DNA
  • Paclitaxel
  • drug delivery
  • nanodiamonds
  • nanomedicine

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