Multiple sclerosis-related white matter microstructural change alters the BOLD hemodynamic response

Nicholas A. Hubbard, Monroe Turner, Joanna L. Hutchison, Austin Ouyang, Jeremy Strain, Larry Oasay, Saranya Sundaram, Scott Davis, Gina Remington, Ryan Brigante, Hao Huang, John Hart, Teresa Frohman, Elliot Frohman, Bharat B. Biswal, Bart Rypma

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Multiple sclerosis (MS) results in inflammatory damage to white matter microstructure. Prior research using blood-oxygen-level dependent (BOLD) imaging indicates MS-related alterations to brain function. What is currently unknown is the extent to which white matter microstructural damage influences BOLD signal in MS. Here we assessed changes in parameters of the BOLD hemodynamic response function (HRF) in patients with relapsing-remitting MS compared to healthy controls. We also used diffusion tensor imaging to assess whether MS-related changes to the BOLD-HRF were affected by changes in white matter microstructural integrity. Our results showed MS-related reductions in BOLD-HRF peak amplitude. These MS-related amplitude decreases were influenced by individual differences in white matter microstructural integrity. Other MS-related factors including altered reaction time, limited spatial extent of BOLD activity, elevated lesion burden, or lesion proximity to regions of interest were not mediators of group differences in BOLD-HRF amplitude. Results are discussed in terms of functional hyperemic mechanisms and implications for analysis of BOLD signal differences.

Original languageEnglish (US)
Pages (from-to)1872-1884
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number11
StatePublished - Nov 1 2016

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


  • Bold contrast
  • brain imaging
  • cerebral hemodynamics
  • multiple sclerosis
  • white matter disease


Dive into the research topics of 'Multiple sclerosis-related white matter microstructural change alters the BOLD hemodynamic response'. Together they form a unique fingerprint.

Cite this