Multispectral transillumination imaging of skin lesions for oxygenated and deoxygenated hemoglobin measurement

Brian D'Alessandro, Atam P. Dhawan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

The early detection of melanoma is critical for patient survival. One of the indentifying features of new malignancy is increased blood flow to the lesion. Multispectral transillumination using the Nevoscope has been demonstrated to be an effective tool for imaging the sub-surface vascular architecture of skin lesions. Using multispectral images obtained from this tool in the visible and near-infrared range, as well as the relative difference in spectral absorption due to oxyhemoglobin and deoxyhemoglobin, we propose an empirical method to estimate the blood flow volume within a skin lesion. From the images, estimates of the distribution of both Hb and HbO2 are calculated along with a ratiometric feature describing the relative oxygen saturation level in the blood. We validate our proposed method through the imaging of a skin phantom with embedded capillaries which can be filled with either an artificial Hb or HbO2 liquid. Our near-IR, multispectral computations nicely differentiate the Hb filled phantom versus the HbO 2 filled phantom, demonstrating that these chromophores can be successfully separated and individually characterized for use in estimating the relative oxygen saturation of skin tissue.

Original languageEnglish (US)
Title of host publication2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Pages6637-6640
Number of pages4
DOIs
StatePublished - Dec 1 2010
Event2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina
Duration: Aug 31 2010Sep 4 2010

Publication series

Name2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Other

Other2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
CountryArgentina
CityBuenos Aires
Period8/31/109/4/10

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Health Informatics

Fingerprint Dive into the research topics of 'Multispectral transillumination imaging of skin lesions for oxygenated and deoxygenated hemoglobin measurement'. Together they form a unique fingerprint.

Cite this