Network homogeneity reveals decreased integrity of default-mode network in ADHD

Lucina Q. Uddin, A. M.Clare Kelly, Bharat B. Biswal, Daniel S. Margulies, Zarrar Shehzad, David Shaw, Manely Ghaffari, John Rotrosen, Lenard A. Adler, F. Xavier Castellanos, Michael P. Milham

Research output: Contribution to journalArticlepeer-review

360 Scopus citations


Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalJournal of Neuroscience Methods
Issue number1
StatePublished - Mar 30 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


  • Attention
  • Attention-deficit/hyperactivity disorder
  • Functional connectivity
  • Posterior cingulate
  • Precuneus
  • Resting state networks
  • fMRI


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