TY - JOUR
T1 - Neural alterations in working memory of mild-moderate TBI
T2 - An fMRI study in Malaysia
AU - Chai, Wen Jia
AU - Abd Hamid, Aini Ismafairus
AU - Omar, Hazim
AU - Abdul Rahman, Muhammad Riddha
AU - Fitzrol, Diana Noma
AU - Idris, Zamzuri
AU - Ghani, Abdul Rahman Izaini
AU - Wan Mohamad, Wan Nor Azlen
AU - Mustafar, Faiz
AU - Hanafi, Muhammad Hafiz
AU - Kandasamy, Regunath
AU - Abdullah, Mohd Zaid
AU - Amaruchkul, Kannapha
AU - Valdes-Sosa, Pedro A.
AU - Bringas-Vega, Maria L.
AU - Biswal, Bharat
AU - Songsiri, Jitkomut
AU - Yaacob, Hamwira
AU - Ibrahim, Haidi
AU - Sumari, Putra
AU - Noh, Nor Azila
AU - Musa, Kamarul Imran
AU - Ahmad, Asma Hayati
AU - Azman, Azlinda
AU - Jamir Singh, Paramjit Singh
AU - Othman, Azizah
AU - Abdullah, Jafri Malin
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2022/4
Y1 - 2022/4
N2 - Working memory (WM) encompasses crucial cognitive processes or abilities to retain and manipulate temporary information for immediate execution of complex cognitive tasks in daily functioning such as reasoning and decision-making. The WM of individuals sustaining traumatic brain injury (TBI) was commonly compromised, especially in the domain of WM. The current study investigated the brain responses of WM in a group of participants with mild–moderate TBI compared to their healthy counterparts employing functional magnetic resonance imaging. All consented participants (healthy: n = 26 and TBI: n = 15) performed two variations of the n-back WM task with four load conditions (0-, 1-, 2-, and 3-back). The respective within-group effects showed a right hemisphere-dominance activation and slower reaction in performance for the TBI group. Random-effects analysis revealed activation difference between the two groups in the right occipital lobe in the guided n-back with cues, and in the bilateral occipital lobe, superior parietal region, and cingulate cortices in the n-back without cues. The left middle frontal gyrus was implicated in the load-dependent processing of WM in both groups. Further group analysis identified that the notable activation changes in the frontal gyri and anterior cingulate cortex are according to low and high loads. Though relatively smaller in scale, this study was eminent as it clarified the neural alterations in WM in the mild–moderate TBI group compared to healthy controls. It confirmed the robustness of the phenomenon in TBI with the reproducibility of the results in a heterogeneous non-Western sample.
AB - Working memory (WM) encompasses crucial cognitive processes or abilities to retain and manipulate temporary information for immediate execution of complex cognitive tasks in daily functioning such as reasoning and decision-making. The WM of individuals sustaining traumatic brain injury (TBI) was commonly compromised, especially in the domain of WM. The current study investigated the brain responses of WM in a group of participants with mild–moderate TBI compared to their healthy counterparts employing functional magnetic resonance imaging. All consented participants (healthy: n = 26 and TBI: n = 15) performed two variations of the n-back WM task with four load conditions (0-, 1-, 2-, and 3-back). The respective within-group effects showed a right hemisphere-dominance activation and slower reaction in performance for the TBI group. Random-effects analysis revealed activation difference between the two groups in the right occipital lobe in the guided n-back with cues, and in the bilateral occipital lobe, superior parietal region, and cingulate cortices in the n-back without cues. The left middle frontal gyrus was implicated in the load-dependent processing of WM in both groups. Further group analysis identified that the notable activation changes in the frontal gyri and anterior cingulate cortex are according to low and high loads. Though relatively smaller in scale, this study was eminent as it clarified the neural alterations in WM in the mild–moderate TBI group compared to healthy controls. It confirmed the robustness of the phenomenon in TBI with the reproducibility of the results in a heterogeneous non-Western sample.
KW - cingulate cortex
KW - functional magnetic resonance imaging
KW - prefrontal cortex
KW - traffic accidents
KW - traumatic brain injury
KW - working memory
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U2 - 10.1002/jnr.25023
DO - 10.1002/jnr.25023
M3 - Article
C2 - 35194817
AN - SCOPUS:85125096197
SN - 0360-4012
VL - 100
SP - 915
EP - 932
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 4
ER -