Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds

Y. S. Lee, G. Collins, T. Livingston Arinzeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

This study evaluated the neural differentiation of human neural stem /progenitor cells (hNPCs) on electrospun fibrous piezoelectric polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) scaffolds. We hypothesize aligned fibrous piezoelectric scaffold would provide both physical cues (via contact guidance) and local electrical activity to promote neuronal differentiation and neurite extension. hNPCs predominately differentiated into the neuronal lineage on both random and aligned electrospun PVDF-TrFE scaffolds. Less nestin-positive hNPCs were present on the scaffolds compared to laminin coated surface. The results suggest the potential use of these scaffolds in spinal cord repair and other neural applications.

Original languageEnglish (US)
Title of host publicationProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
DOIs
StatePublished - Jun 8 2010
Event36th Annual Northeast Bioengineering Conference, NEBEC 2010 - New York, NY, United States
Duration: Mar 26 2010Mar 28 2010

Publication series

NameProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010

Other

Other36th Annual Northeast Bioengineering Conference, NEBEC 2010
CountryUnited States
CityNew York, NY
Period3/26/103/28/10

All Science Journal Classification (ASJC) codes

  • Bioengineering

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