Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds

Y. S. Lee; G. Collins; T. Livingston Arinzeh

doi:10.1109/NEBC.2010.5458264

Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds

Y. S. Lee, G. Collins, T. Livingston Arinzeh

Bio-Medical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

This study evaluated the neural differentiation of human neural stem /progenitor cells (hNPCs) on electrospun fibrous piezoelectric polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) scaffolds. We hypothesize aligned fibrous piezoelectric scaffold would provide both physical cues (via contact guidance) and local electrical activity to promote neuronal differentiation and neurite extension. hNPCs predominately differentiated into the neuronal lineage on both random and aligned electrospun PVDF-TrFE scaffolds. Less nestin-positive hNPCs were present on the scaffolds compared to laminin coated surface. The results suggest the potential use of these scaffolds in spinal cord repair and other neural applications.

Original language	English (US)
Title of host publication	Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
DOIs	https://doi.org/10.1109/NEBC.2010.5458264
State	Published - 2010
Event	36th Annual Northeast Bioengineering Conference, NEBEC 2010 - New York, NY, United States Duration: Mar 26 2010 → Mar 28 2010

Publication series

Name	Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010

Other

Other	36th Annual Northeast Bioengineering Conference, NEBEC 2010
Country/Territory	United States
City	New York, NY
Period	3/26/10 → 3/28/10

All Science Journal Classification (ASJC) codes

Bioengineering

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10.1109/NEBC.2010.5458264

Cite this

Lee, Y. S., Collins, G., & Arinzeh, T. L. (2010). Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds. In Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010 Article 5458264 (Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010). https://doi.org/10.1109/NEBC.2010.5458264

@inproceedings{6a0f08fbcac84ee8ae3f3851251f8d0f,

title = "Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds",

abstract = "This study evaluated the neural differentiation of human neural stem /progenitor cells (hNPCs) on electrospun fibrous piezoelectric polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) scaffolds. We hypothesize aligned fibrous piezoelectric scaffold would provide both physical cues (via contact guidance) and local electrical activity to promote neuronal differentiation and neurite extension. hNPCs predominately differentiated into the neuronal lineage on both random and aligned electrospun PVDF-TrFE scaffolds. Less nestin-positive hNPCs were present on the scaffolds compared to laminin coated surface. The results suggest the potential use of these scaffolds in spinal cord repair and other neural applications.",

author = "Lee, {Y. S.} and G. Collins and Arinzeh, {T. Livingston}",

year = "2010",

doi = "10.1109/NEBC.2010.5458264",

language = "English (US)",

isbn = "9781424468799",

series = "Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010",

booktitle = "Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010",

note = "36th Annual Northeast Bioengineering Conference, NEBEC 2010 ; Conference date: 26-03-2010 Through 28-03-2010",

}

Lee, YS, Collins, G & Arinzeh, TL 2010, Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds. in Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010., 5458264, Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010, 36th Annual Northeast Bioengineering Conference, NEBEC 2010, New York, NY, United States, 3/26/10. https://doi.org/10.1109/NEBC.2010.5458264

Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds. / Lee, Y. S.; Collins, G.; Arinzeh, T. Livingston.
Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010. 2010. 5458264 (Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds

AU - Lee, Y. S.

AU - Collins, G.

AU - Arinzeh, T. Livingston

PY - 2010

Y1 - 2010

N2 - This study evaluated the neural differentiation of human neural stem /progenitor cells (hNPCs) on electrospun fibrous piezoelectric polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) scaffolds. We hypothesize aligned fibrous piezoelectric scaffold would provide both physical cues (via contact guidance) and local electrical activity to promote neuronal differentiation and neurite extension. hNPCs predominately differentiated into the neuronal lineage on both random and aligned electrospun PVDF-TrFE scaffolds. Less nestin-positive hNPCs were present on the scaffolds compared to laminin coated surface. The results suggest the potential use of these scaffolds in spinal cord repair and other neural applications.

AB - This study evaluated the neural differentiation of human neural stem /progenitor cells (hNPCs) on electrospun fibrous piezoelectric polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) scaffolds. We hypothesize aligned fibrous piezoelectric scaffold would provide both physical cues (via contact guidance) and local electrical activity to promote neuronal differentiation and neurite extension. hNPCs predominately differentiated into the neuronal lineage on both random and aligned electrospun PVDF-TrFE scaffolds. Less nestin-positive hNPCs were present on the scaffolds compared to laminin coated surface. The results suggest the potential use of these scaffolds in spinal cord repair and other neural applications.

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U2 - 10.1109/NEBC.2010.5458264

DO - 10.1109/NEBC.2010.5458264

M3 - Conference contribution

AN - SCOPUS:77953071156

SN - 9781424468799

T3 - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010

BT - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010

T2 - 36th Annual Northeast Bioengineering Conference, NEBEC 2010

Y2 - 26 March 2010 through 28 March 2010

ER -

Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds

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