Neural mechanisms for generating rate and temporal codes in model CA3 pyramidal cells

V. Booth, A. Bose

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The effect of synaptic inhibition on burst firing of a two-compartment model of a CA3 pyramidal cell is considered. We show that, depending on its timing, a short dose of fast decaying synaptic inhibition can either delay or advance the timing of firing of subsequent bursts. Moreover, increasing the strength of the inhibitory input is shown to modulate the burst profile from a full complex burst, to a burst with multiple spikes, to single spikes. We additionally show how slowly decaying inhibitory input can be used to synchronize a network of pyramidal cells. Implications for the phase precession phenomenon of hippocampal place cells and for the generation of temporal and rate codes are discussed.

Original languageEnglish (US)
Pages (from-to)2432-2445
Number of pages14
JournalJournal of neurophysiology
Volume85
Issue number6
DOIs
StatePublished - Jan 1 2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Fingerprint Dive into the research topics of 'Neural mechanisms for generating rate and temporal codes in model CA3 pyramidal cells'. Together they form a unique fingerprint.

Cite this