Neuroplasticity in vision dysfunction

Tara L. Alvarez, Yelda Alkan, Eun Kim, Rajbir Jaswal, Diana Ludlam, Phillipe Moinot, Bharat B. Biswal, Vincent R. Vicci

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Adaptation is critical to the survival of any species and is present in many systems within the brain. Rehabilitation can evoke neuroplasticity through adaptive mechanisms. Four subjects with the vision dysfunction of convergence insufficiency where two have mild traumatic brain injury and two were congenital participated in 18 hours of vision training. Clinical, behavioral, functional imaging and diffusion tensor imaging (DTI) are measured before and after therapy. Clinical parameters show improvement. Vergence eye-movements show an increase in peak velocity where independent component analysis revealed an increase in the magnitude of the preprogrammed transient component. Functional imaging using an oculomotor learning task shows increased area and intensity of activation suggesting neuronal recruitment and synchronization. DTI shows an increase in fractional anisotropy and an increase in the number of fibers suggesting changes in structural connectivity. Preliminary data suggest that neuroplasticity from vision training results in a change in behavioral oculomotor neural control through an increased magnitude of the preprogrammed disparity transient component potentially caused in part by neuronal recruitment, synchronization and improved structural connectivity.

Original languageEnglish (US)
Title of host publication2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09
Number of pages4
StatePublished - 2009
Event2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 - Antalya, Turkey
Duration: Apr 29 2009May 2 2009

Publication series

Name2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09


Other2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Clinical Neurology
  • General Neuroscience


  • Diffusion tensor imaging
  • Functional MRI
  • Neuroplasticity
  • Oculomotor control
  • Vergence
  • Vision therapy


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