Neutral rhodol-based dyes expressing localization in mitochondria

Ilaria Ferraboschi, Juraj Ovčar, Kateryna V. Vygranenko, Shupei Yu, Alfonso Minervino, Antoni Wrzosek, Adam Szewczyk, Riccardo Rozza, Alessandra Magistrato, Kevin D. Belfield, Daniel T. Gryko, Luca Grisanti, Cristina Sissa

Research output: Contribution to journalArticlepeer-review

Abstract

Neutral rhodol-based red emitters are shown to efficiently localize in mitochondria, as demonstrated by confocal microscopy and co-localization studies. A simple model is proposed to explain the localization mechanism of neutral molecules. The model takes into account the strong coupling between the molecular dipole moment and the electric field of the inner mitochondrial membrane.

Original languageEnglish (US)
JournalOrganic and Biomolecular Chemistry
DOIs
StateAccepted/In press - 2024

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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