New technology to reduce complications and procedure time in cranial and spinal surgery

Piyush Modak, Willis Hammond, Michael Jaffe, Malavika Nadig, Richard Russo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Commercially available absorbable surgical hemostats swell in use (20-200%) because they absorb fluids and can compress the neighboring tissues leading to complications. This is especially a problem in cranial and spine surgery because the swollen hemostats cause neural compression leading to pain, paresis, and paralysis [1]. Such hemostats are also slow acting and can take up to 10 minutes to achieve hemostasis, and these are often used several times per case. In this study, we present a patented system of two natural polysaccharides that form a hydrogel device in situ without the use of an external crosslinking agent. Even though one of the starting materials in our system, chitosan, has been shown to be hemostatic in in vitro tests, more appropriate testing using in vivo critical defect models demonstrated it to be not hemostatic [2]. We have chemically modified the chitosan to be water-soluble so that it interacts with oxidized dextran via Schiff base formation to form a unique hydrogel structure that: 1) produces hemostasis in a short time, 2) leads to stable clot formation and 3) gently shrinks with time.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages740
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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