Novel BODIPY-based fluorescence turn-on sensor for Fe3+ and its bioimaging application in living cells

Binglin Sui; Simon Tang; Taihong Liu; Bosung Kim; Kevin D. Belfield

doi:10.1021/am506262u

Novel BODIPY-based fluorescence turn-on sensor for Fe³⁺ and its bioimaging application in living cells

Binglin Sui, Simon Tang, Taihong Liu, Bosung Kim, Kevin D. Belfield

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

A novel boron-dipyrromethene (BODIPY) based fluorescence turn-on sensor for detecting Fe³⁺ in aqueous media is reported with 23-fold fluorescence enhancement. The sensor is comprised of a combination of BODIPY fluorophore and a new Fe³⁺-recognizing cryptand that exhibits high selectivity, sensitivity, and reversibility toward Fe³⁺ detection. Cell imaging studies demonstrate that this sensor is capable of sensing Fe³⁺ in living cells.

Original language	English (US)
Pages (from-to)	18408-18412
Number of pages	5
Journal	ACS Applied Materials and Interfaces
Volume	6
Issue number	21
DOIs	https://doi.org/10.1021/am506262u
State	Published - Nov 12 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Materials Science

Keywords

BODIPY
cell imaging
cryptand
fluorescent sensor
iron(III)
metal ion sensor

Access to Document

10.1021/am506262u

Cite this

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title = "Novel BODIPY-based fluorescence turn-on sensor for Fe3+ and its bioimaging application in living cells",

abstract = "A novel boron-dipyrromethene (BODIPY) based fluorescence turn-on sensor for detecting Fe3+ in aqueous media is reported with 23-fold fluorescence enhancement. The sensor is comprised of a combination of BODIPY fluorophore and a new Fe3+-recognizing cryptand that exhibits high selectivity, sensitivity, and reversibility toward Fe3+ detection. Cell imaging studies demonstrate that this sensor is capable of sensing Fe3+ in living cells.",

keywords = "BODIPY, cell imaging, cryptand, fluorescent sensor, iron(III), metal ion sensor",

author = "Binglin Sui and Simon Tang and Taihong Liu and Bosung Kim and Belfield, {Kevin D.}",

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AU - Sui, Binglin

AU - Tang, Simon

AU - Liu, Taihong

AU - Kim, Bosung

AU - Belfield, Kevin D.

PY - 2014/11/12

Y1 - 2014/11/12

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AB - A novel boron-dipyrromethene (BODIPY) based fluorescence turn-on sensor for detecting Fe3+ in aqueous media is reported with 23-fold fluorescence enhancement. The sensor is comprised of a combination of BODIPY fluorophore and a new Fe3+-recognizing cryptand that exhibits high selectivity, sensitivity, and reversibility toward Fe3+ detection. Cell imaging studies demonstrate that this sensor is capable of sensing Fe3+ in living cells.

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KW - cryptand

KW - fluorescent sensor

KW - iron(III)

KW - metal ion sensor

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