Novel BODIPY-based fluorescence turn-on sensor for Fe3+ and its bioimaging application in living cells

Binglin Sui, Simon Tang, Taihong Liu, Bosung Kim, Kevin D. Belfield

Research output: Contribution to journalArticlepeer-review

124 Scopus citations


A novel boron-dipyrromethene (BODIPY) based fluorescence turn-on sensor for detecting Fe3+ in aqueous media is reported with 23-fold fluorescence enhancement. The sensor is comprised of a combination of BODIPY fluorophore and a new Fe3+-recognizing cryptand that exhibits high selectivity, sensitivity, and reversibility toward Fe3+ detection. Cell imaging studies demonstrate that this sensor is capable of sensing Fe3+ in living cells.

Original languageEnglish (US)
Pages (from-to)18408-18412
Number of pages5
JournalACS Applied Materials and Interfaces
Issue number21
StatePublished - Nov 12 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)


  • cell imaging
  • cryptand
  • fluorescent sensor
  • iron(III)
  • metal ion sensor


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