Abstract
An amperometric biosensor for monitoring the level of saliva protein histatin is described. The biosensor-sensing elements comprise a layer of salivary histatin antibody self-assembled onto a gold quartz crystal by covalent attachment. The biospecific interaction between the immobilized histatin antibody and histatin antigen was monitored via a novel electroactive indicator, silver monodispersed on the gold surface. The silver is oxidized or reduced and the resulting peak currents provide analytical information about the concentrations of the salivary proteins. A detection limit of 0.626 pg/ml was obtained.
Original language | English (US) |
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Pages (from-to) | 161-163 |
Number of pages | 3 |
Journal | Sensor Letters |
Volume | 3 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2005 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering
Keywords
- Amperometry
- Electrochemical biosensor
- Histatin
- Saliva