Novel electrochemical oral biosensor for histatin

A. O. Aluoch, K. Amrute, O. A. Sadik

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


An amperometric biosensor for monitoring the level of saliva protein histatin is described. The biosensor-sensing elements comprise a layer of salivary histatin antibody self-assembled onto a gold quartz crystal by covalent attachment. The biospecific interaction between the immobilized histatin antibody and histatin antigen was monitored via a novel electroactive indicator, silver monodispersed on the gold surface. The silver is oxidized or reduced and the resulting peak currents provide analytical information about the concentrations of the salivary proteins. A detection limit of 0.626 pg/ml was obtained.

Original languageEnglish (US)
Pages (from-to)161-163
Number of pages3
JournalSensor Letters
Issue number2
StatePublished - Jun 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


  • Amperometry
  • Electrochemical biosensor
  • Histatin
  • Saliva


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