Preparation of [ 18 F]fluoroarenes with nucleophilic [ 18 F]fluoride for positron emission tomography (PET) molecular imaging research is a challenging chemical endeavor. Advances in radiofluorination have soared in the last decade, broadening the availability of potential [ 18 F]fluoroarenes. In this Synpacts article, we highlight the recent development from our laboratory of a practical radiofluorination of anilines via N arylsydnone intermediates to afford [ 18 F]fluoroarenes. Further, we emphasize the utility of this methodology towards peptide labeling applications by preparing an 18 F-labeled neuropeptide. 1 Introduction 2 Nucleophilic Radiofluorination of N -Arylsydnones 3 Substrate Scope and Applications 4 Conclusion.
All Science Journal Classification (ASJC) codes
- Organic Chemistry
- bioorthogonal chemistry
- peptide labeling