Abstract
Preparation of [ 18 F]fluoroarenes with nucleophilic [ 18 F]fluoride for positron emission tomography (PET) molecular imaging research is a challenging chemical endeavor. Advances in radiofluorination have soared in the last decade, broadening the availability of potential [ 18 F]fluoroarenes. In this Synpacts article, we highlight the recent development from our laboratory of a practical radiofluorination of anilines via N arylsydnone intermediates to afford [ 18 F]fluoroarenes. Further, we emphasize the utility of this methodology towards peptide labeling applications by preparing an 18 F-labeled neuropeptide. 1 Introduction 2 Nucleophilic Radiofluorination of N -Arylsydnones 3 Substrate Scope and Applications 4 Conclusion.
Original language | English (US) |
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Pages (from-to) | 1131-1135 |
Number of pages | 5 |
Journal | Synlett |
Volume | 29 |
Issue number | 9 |
DOIs | |
State | Published - Jun 1 2018 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Organic Chemistry
Keywords
- bioorthogonal chemistry
- fluorine-18
- fluoroarene
- peptide labeling
- sydnone