Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

Guillermo H. Jimenez-Aleman; Marilia Almeida-Trapp; Gemma Fernández-Barbero; Selena Gimenez-Ibanez; Michael Reichelt; Jyothilakshmi Vadassery; Axel Mithöfer; Julio Caballero; Wilhelm Boland; Roberto Solano

doi:10.1016/j.bbalip.2019.158520

Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

Guillermo H. Jimenez-Aleman
, Marilia Almeida-Trapp
, Gemma Fernández-Barbero
, Selena Gimenez-Ibanez
, Michael Reichelt
, Jyothilakshmi Vadassery
, Axel Mithöfer
, Julio Caballero
, Wilhelm Boland
, Roberto Solano

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.

Original language	English (US)
Article number	158520
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	1864
Issue number	12
DOIs	https://doi.org/10.1016/j.bbalip.2019.158520
State	Published - Dec 2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

Keywords

Fatty acids
Jasmonate
Oxylipin
Phytohormone
ω-Hydroxylation

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10.1016/j.bbalip.2019.158520

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Jimenez-Aleman, G. H., Almeida-Trapp, M., Fernández-Barbero, G., Gimenez-Ibanez, S., Reichelt, M., Vadassery, J., Mithöfer, A., Caballero, J., Boland, W., & Solano, R. (2019). Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(12), Article 158520. https://doi.org/10.1016/j.bbalip.2019.158520

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title = "Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway",

abstract = "Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.",

keywords = "Fatty acids, Jasmonate, Oxylipin, Phytohormone, ω-Hydroxylation",

author = "Jimenez-Aleman, \{Guillermo H.\} and Marilia Almeida-Trapp and Gemma Fern{\'a}ndez-Barbero and Selena Gimenez-Ibanez and Michael Reichelt and Jyothilakshmi Vadassery and Axel Mith{\"o}fer and Julio Caballero and Wilhelm Boland and Roberto Solano",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = dec,

doi = "10.1016/j.bbalip.2019.158520",

language = "English (US)",

volume = "1864",

journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

issn = "1388-1981",

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}

Jimenez-Aleman, GH, Almeida-Trapp, M, Fernández-Barbero, G, Gimenez-Ibanez, S, Reichelt, M, Vadassery, J, Mithöfer, A, Caballero, J, Boland, W & Solano, R 2019, 'Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1864, no. 12, 158520. https://doi.org/10.1016/j.bbalip.2019.158520

Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway. / Jimenez-Aleman, Guillermo H.; Almeida-Trapp, Marilia; Fernández-Barbero, Gemma et al.
In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1864, No. 12, 158520, 12.2019.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

AU - Jimenez-Aleman, Guillermo H.

AU - Almeida-Trapp, Marilia

AU - Fernández-Barbero, Gemma

AU - Gimenez-Ibanez, Selena

AU - Reichelt, Michael

AU - Vadassery, Jyothilakshmi

AU - Mithöfer, Axel

AU - Caballero, Julio

AU - Boland, Wilhelm

AU - Solano, Roberto

PY - 2019/12

Y1 - 2019/12

N2 - Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.

AB - Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.

KW - Fatty acids

KW - Jasmonate

KW - Oxylipin

KW - Phytohormone

KW - ω-Hydroxylation

UR - https://www.scopus.com/pages/publications/85071839680

UR - https://www.scopus.com/pages/publications/85071839680#tab=citedBy

U2 - 10.1016/j.bbalip.2019.158520

DO - 10.1016/j.bbalip.2019.158520

M3 - Article

C2 - 31473347

AN - SCOPUS:85071839680

SN - 1388-1981

VL - 1864

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 12

M1 - 158520

ER -

Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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