Abstract
The concept of k-FWER has received much attention lately as an appropriate error rate for multiple testing when one seeks to control at least k false rejections, for some fixed k = ≥. A less conservative notion, the k-FDR, has been introduced very recently by Sarkar [Ann. Statist. 34 (2006) 394-415], generalizing the false discovery rate of Benjamini and Hochberg [J. Roy. Statist. Soc. Ser. B 57 (1995) 289-300]. In this article, we bring newer insight to the k-FDR considering a mixture model involving independent p-values before motivating the developments of some new procedures that control it. We prove the k-FDR control of the proposed methods under a slightly weaker condition than in the mixture model. We provide numerical evidence of the proposed methods' superior power performance over some k-FWER and k- FDR methods. Finally, we apply our methods to a real data set.
Original language | English (US) |
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Pages (from-to) | 1545-1565 |
Number of pages | 21 |
Journal | Annals of Statistics |
Volume | 37 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2009 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Statistics and Probability
- Statistics, Probability and Uncertainty
Keywords
- Average power
- Gene expression
- Generalized FDR
- Generalized FWER
- Multiple hypothesis testing
- Oracle k-FDR procedure
- Stepup procedures