One-pot synthesis and surface modification of lauric-acid-capped CoFe2O4 nanoparticles

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This paper presents a facile one-pot method to synthesize monodisperse lauric-acid-capped cobalt ferrite nanoparticles (CoFe2O4 NPs)and investigates their potential application as drug carriers for loading and controlled release of doxorubicin (DOX). The lauric-acid-capped CoFe2O4 NPs with a particle size of 15.3 ± 1.7 nm were synthesized via one-pot reaction. Water-soluble lauric-acid-capped CoFe2O4 NPs were obtained through surface modification with cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS). Furthermore, the performance of water-soluble lauric-acid-capped CoFe2O4 NPs for drug delivery was investigated with DOX hydrochloride. The DOX release percentages of CTAB and SDS modified lauric-acid-capped CoFe2O4 NPs are 56.1% and 48.2%, respectively. These results indicated that the modified lauric-acid-capped CoFe2O4 NPs could be utilized as a promising candidate for cancer chemotherapy by making use of their pH-sensitive drug-release properties.

Original languageEnglish (US)
Article number8369384
JournalIEEE Transactions on Magnetics
Issue number11
StatePublished - Nov 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering


  • Drug delivery
  • inverse spinel cobalt ferrite (CoFe2O3)
  • one-pot method
  • surface modification


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