One-pot synthesis and surface modification of lauric-acid-capped CoFe2O4 nanoparticles

Yun Teng; Philip W.T. Pong

doi:10.1109/TMAG.2018.2834524

One-pot synthesis and surface modification of lauric-acid-capped CoFe₂O₄ nanoparticles

Yun Teng, Philip W.T. Pong

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This paper presents a facile one-pot method to synthesize monodisperse lauric-acid-capped cobalt ferrite nanoparticles (CoFe₂O₄ NPs)and investigates their potential application as drug carriers for loading and controlled release of doxorubicin (DOX). The lauric-acid-capped CoFe₂O₄ NPs with a particle size of 15.3 ± 1.7 nm were synthesized via one-pot reaction. Water-soluble lauric-acid-capped CoFe₂O₄ NPs were obtained through surface modification with cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS). Furthermore, the performance of water-soluble lauric-acid-capped CoFe₂O₄ NPs for drug delivery was investigated with DOX hydrochloride. The DOX release percentages of CTAB and SDS modified lauric-acid-capped CoFe₂O₄ NPs are 56.1% and 48.2%, respectively. These results indicated that the modified lauric-acid-capped CoFe₂O₄ NPs could be utilized as a promising candidate for cancer chemotherapy by making use of their pH-sensitive drug-release properties.

Original language	English (US)
Article number	8369384
Journal	IEEE Transactions on Magnetics
Volume	54
Issue number	11
DOIs	https://doi.org/10.1109/TMAG.2018.2834524
State	Published - Nov 2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

Keywords

Drug delivery
inverse spinel cobalt ferrite (CoFe2O3)
one-pot method
surface modification

Access to Document

10.1109/TMAG.2018.2834524

Cite this

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title = "One-pot synthesis and surface modification of lauric-acid-capped CoFe2O4 nanoparticles",

abstract = "This paper presents a facile one-pot method to synthesize monodisperse lauric-acid-capped cobalt ferrite nanoparticles (CoFe2O4 NPs)and investigates their potential application as drug carriers for loading and controlled release of doxorubicin (DOX). The lauric-acid-capped CoFe2O4 NPs with a particle size of 15.3 ± 1.7 nm were synthesized via one-pot reaction. Water-soluble lauric-acid-capped CoFe2O4 NPs were obtained through surface modification with cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS). Furthermore, the performance of water-soluble lauric-acid-capped CoFe2O4 NPs for drug delivery was investigated with DOX hydrochloride. The DOX release percentages of CTAB and SDS modified lauric-acid-capped CoFe2O4 NPs are 56.1% and 48.2%, respectively. These results indicated that the modified lauric-acid-capped CoFe2O4 NPs could be utilized as a promising candidate for cancer chemotherapy by making use of their pH-sensitive drug-release properties.",

keywords = "Drug delivery, inverse spinel cobalt ferrite (CoFe2O3), one-pot method, surface modification",

author = "Yun Teng and Pong, {Philip W.T.}",

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N2 - This paper presents a facile one-pot method to synthesize monodisperse lauric-acid-capped cobalt ferrite nanoparticles (CoFe2O4 NPs)and investigates their potential application as drug carriers for loading and controlled release of doxorubicin (DOX). The lauric-acid-capped CoFe2O4 NPs with a particle size of 15.3 ± 1.7 nm were synthesized via one-pot reaction. Water-soluble lauric-acid-capped CoFe2O4 NPs were obtained through surface modification with cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS). Furthermore, the performance of water-soluble lauric-acid-capped CoFe2O4 NPs for drug delivery was investigated with DOX hydrochloride. The DOX release percentages of CTAB and SDS modified lauric-acid-capped CoFe2O4 NPs are 56.1% and 48.2%, respectively. These results indicated that the modified lauric-acid-capped CoFe2O4 NPs could be utilized as a promising candidate for cancer chemotherapy by making use of their pH-sensitive drug-release properties.

AB - This paper presents a facile one-pot method to synthesize monodisperse lauric-acid-capped cobalt ferrite nanoparticles (CoFe2O4 NPs)and investigates their potential application as drug carriers for loading and controlled release of doxorubicin (DOX). The lauric-acid-capped CoFe2O4 NPs with a particle size of 15.3 ± 1.7 nm were synthesized via one-pot reaction. Water-soluble lauric-acid-capped CoFe2O4 NPs were obtained through surface modification with cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS). Furthermore, the performance of water-soluble lauric-acid-capped CoFe2O4 NPs for drug delivery was investigated with DOX hydrochloride. The DOX release percentages of CTAB and SDS modified lauric-acid-capped CoFe2O4 NPs are 56.1% and 48.2%, respectively. These results indicated that the modified lauric-acid-capped CoFe2O4 NPs could be utilized as a promising candidate for cancer chemotherapy by making use of their pH-sensitive drug-release properties.

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