One-Step Regio- and Stereoselective Electrochemical Synthesis of Orexin Receptor Antagonist Oxidative Metabolites

Keyphrases

• Regio 100%
• Orexin Receptors 100%
• Regioselectivity 100%
• Stereoselectivity 100%
• Electrochemical Synthesis 100%
• Oxidative Metabolites 100%
• Electrochemical Oxidation 66%
• Secondary Carbon 66%
• Carbon Radicals 66%
• Complex Structure 33%
• Drug Metabolites 33%
• Metabolism 33%
• Drug Candidates 33%
• Aqueous Media 33%
• Density Functional Calculations 33%
• Pico 33%
• Steric Hindrance 33%
• Transition State 33%
• Hydroxyl 33%
• Synthetic Routes 33%
• Amides 33%
• Piperidone 33%
• Amide Group 33%
• Multiple Steps 33%
• Mass Spectrometry Platform 33%
• Electrochemistry-mass Spectrometry 33%
• Reaction Screening 33%
• High-resolution Magnetic Resonance 33%
• Pharmacokinetic Properties 33%
• Safety Profile 33%
• Resonance Characterization 33%

Chemistry

• Metabolite 100%
• Electrochemical Oxidation 100%
• Carboxamide 100%
• Regioselectivity 100%
• Stereoselectivity 100%
• Orexin Receptor Antagonist 100%
• Mass Spectrometry 50%
• Electrochemistry 50%
• Drug Metabolite 50%
• Density Functional Theory 50%
• Cation 50%
• Energetics 50%
• Pharmacokinetics 50%
• Hydroxyl 50%
• Transition State 50%
• Steric Hindrance 50%
• High-Resolution Nuclear Magnetic Resonance 50%

Biochemistry, Genetics and Molecular Biology

• Metabolite 100%
• Receptor Antagonist 100%
• Orexin Receptor 100%
• Alpha Oxidation 66%
• Stereoselectivity 66%
• Regioselectivity 66%
• Metabolic Pathway 33%
• Conformation 33%
• Mass Spectrometry 33%
• Energy Transfer 33%
• Magnetism 33%
• Mole (Insectivora) 33%
• Stereospecificity 33%
• Pharmacokinetic Properties 33%