Optogenetics in a transparent animal: Circuit function in the larval zebrafish

Ruben Portugues, Kristen E. Severi, Claire Wyart, Misha B. Ahrens

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations

Abstract

Optogenetic tools can be used to manipulate neuronal activity in a reversible and specific manner. In recent years, such methods have been applied to uncover causal relationships between activity in specified neuronal circuits and behavior in the larval zebrafish. In this small, transparent, genetic model organism, noninvasive manipulation and monitoring of neuronal activity with light is possible throughout the nervous system. Here we review recent work in which these new tools have been applied to zebrafish, and discuss some of the existing challenges of these approaches.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume23
Issue number1
DOIs
StatePublished - Feb 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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