Organic reactions of ionic intermediates promoted by atmospheric-pressure thermal activation

Hao Chen, Livia S. Eberlin, Marcela Nefliu, Rodinei Augusti, R. Graham Cooks

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

(Chemical Equation Presented) A mild-mannered process: Novel methodology, in which electrosonic spray ionization (ESSI, see schematic diagram) is used as the proton source, has been used to generate ionic reaction intermediates whose conversion into products can be promoted by atmospheric-pressure thermal activation. Reactions performed under these mild conditions include Borsche-Drechsel cyclization, Fischer indole synthesis, and pinacol rearrangement.

Original languageEnglish (US)
Pages (from-to)3422-3425
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number18
DOIs
StatePublished - Apr 21 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • Green chemistry
  • Mass spectrometry
  • Protonation
  • Reaction intermediates
  • Synthetic methods

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