Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation

Emily C. MacDuffie; Luis Cocka; Xiang Lin; Memory Bvochora-Nsingo; Sebathu Chiyapo; Dawn Balang; Bokang Maswabi; Kebatshabile Ngoni; Doreen Ramogola-Masire; Nicola M. Zetola; Zhi Wei; Hao Shen; Sheynaz Bassa; Surbhi Grover; Erle S. Robertson

doi:10.1158/2767-9764.CRC-24-0364

Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation

Emily C. MacDuffie, Luis Cocka, Xiang Lin, Memory Bvochora-Nsingo, Sebathu Chiyapo, Dawn Balang, Bokang Maswabi, Kebatshabile Ngoni, Doreen Ramogola-Masire, Nicola M. Zetola, Zhi Wei, Hao Shen, Sheynaz Bassa, Surbhi Grover, Erle S. Robertson

Research output: Contribution to journal › Article › peer-review

Abstract

SIGNIFICANCE: Chemoradiation affects the immune system of patients with cervical cancer with well-controlled HIV infection differently than those without HIV, yet their survival does not differ. This finding is an important step in understanding how management of HIV infection can modify cancer outcomes, particularly in settings with a high burden of HIV.

Original language	English (US)
Pages (from-to)	610-620
Number of pages	11
Journal	Cancer Research Communications
Volume	5
Issue number	4
DOIs	https://doi.org/10.1158/2767-9764.CRC-24-0364
State	Published - Apr 1 2025
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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10.1158/2767-9764.CRC-24-0364

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MacDuffie, E. C., Cocka, L., Lin, X., Bvochora-Nsingo, M., Chiyapo, S., Balang, D., Maswabi, B., Ngoni, K., Ramogola-Masire, D., Zetola, N. M., Wei, Z., Shen, H., Bassa, S., Grover, S., & Robertson, E. S. (2025). Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation. Cancer Research Communications, 5(4), 610-620. https://doi.org/10.1158/2767-9764.CRC-24-0364

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title = "Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation",

abstract = "SIGNIFICANCE: Chemoradiation affects the immune system of patients with cervical cancer with well-controlled HIV infection differently than those without HIV, yet their survival does not differ. This finding is an important step in understanding how management of HIV infection can modify cancer outcomes, particularly in settings with a high burden of HIV.",

author = "MacDuffie, \{Emily C.\} and Luis Cocka and Xiang Lin and Memory Bvochora-Nsingo and Sebathu Chiyapo and Dawn Balang and Bokang Maswabi and Kebatshabile Ngoni and Doreen Ramogola-Masire and Zetola, \{Nicola M.\} and Zhi Wei and Hao Shen and Sheynaz Bassa and Surbhi Grover and Robertson, \{Erle S.\}",

note = "Publisher Copyright: {\textcopyright}2025 The Authors; Published by the American Association for Cancer Research.",

year = "2025",

month = apr,

day = "1",

doi = "10.1158/2767-9764.CRC-24-0364",

language = "English (US)",

volume = "5",

pages = "610--620",

journal = "Cancer Research Communications",

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publisher = "American Association for Cancer Research Inc.",

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MacDuffie, EC, Cocka, L, Lin, X, Bvochora-Nsingo, M, Chiyapo, S, Balang, D, Maswabi, B, Ngoni, K, Ramogola-Masire, D, Zetola, NM, Wei, Z, Shen, H, Bassa, S, Grover, S & Robertson, ES 2025, 'Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation', Cancer Research Communications, vol. 5, no. 4, pp. 610-620. https://doi.org/10.1158/2767-9764.CRC-24-0364

TY - JOUR

T1 - Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation

AU - MacDuffie, Emily C.

AU - Cocka, Luis

AU - Lin, Xiang

AU - Bvochora-Nsingo, Memory

AU - Chiyapo, Sebathu

AU - Balang, Dawn

AU - Maswabi, Bokang

AU - Ngoni, Kebatshabile

AU - Ramogola-Masire, Doreen

AU - Zetola, Nicola M.

AU - Wei, Zhi

AU - Shen, Hao

AU - Bassa, Sheynaz

AU - Grover, Surbhi

AU - Robertson, Erle S.

PY - 2025/4/1

Y1 - 2025/4/1

N2 - SIGNIFICANCE: Chemoradiation affects the immune system of patients with cervical cancer with well-controlled HIV infection differently than those without HIV, yet their survival does not differ. This finding is an important step in understanding how management of HIV infection can modify cancer outcomes, particularly in settings with a high burden of HIV.

AB - SIGNIFICANCE: Chemoradiation affects the immune system of patients with cervical cancer with well-controlled HIV infection differently than those without HIV, yet their survival does not differ. This finding is an important step in understanding how management of HIV infection can modify cancer outcomes, particularly in settings with a high burden of HIV.

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U2 - 10.1158/2767-9764.CRC-24-0364

DO - 10.1158/2767-9764.CRC-24-0364

M3 - Article

C2 - 40099965

AN - SCOPUS:105003602225

SN - 2767-9764

VL - 5

SP - 610

EP - 620

JO - Cancer Research Communications

JF - Cancer Research Communications

IS - 4

ER -

Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation

Abstract

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